无创技术评估肺动脉高压患者右心功能的相关性分析  被引量:25

Assessing right ventricular function in patients with pulmonary artery hypertension based on noninvasive measurements:correlation between cardiac MRI, ultrasonic cardiogram, multidetector CT and right heart catheterization

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作  者:郭晓娟[1] 刘明熙[1] 马展鸿[1] 蒋涛[1] 杨媛华[2] 龚娟妮[2] 刘敏[3] Guo Xiaojuan;Liu Mingxi;Ma Zhanhong;Jiang Tao;Yang Yuanhua;Gong Juanni;Liu Min(Department of Radiology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区:[1]首都医科大学附属北京朝阳医院放射科,100020 [2]首都医科大学附属北京朝阳医院呼吸科,100020 [3]首都医科大学附属北京朝阳医院卫生部北京中日医院放射科100020

出  处:《中华医学杂志》2018年第43期3528-3531,共4页National Medical Journal of China

基  金:国家重点研发计划项目(2016YFC0905602);北京自然科学基金(7182149)

摘  要:目的以右心导管检查为金标准,比较心脏磁共振成像(CMRI),心动超声检查(UCG),多层螺旋CT(MDCT)对肺动脉高压(PAH)患者的右心功能的评估价值。方法前瞻性收集2012年8月至2014年2月北京朝阳医院治疗的PAH患者31例,男17例、女14例,平均年龄33—76(55±12)岁。CMRI测量右室收缩末期/舒张末期容积(ESV、EDV)、每博量(SV)及射血分数(EF),标化右室心肌质量(VMI)。UCG测量右室Tei指数,面积变化率(FAC),ESV、EDV。MDCT测量右室形态学指标。采用Pearson或Spearman相关系数进行相关分析。结果CMRI.EF(40±9),VMI44~115(71±20)g/m2,CT测量脊柱室间隔角(Cobb角)(67°±12°)与6分钟步行距离具有负性中度相关性;CMRI—SV(57±21)ml,EF,VMI,UCG—EF(41±14),Tei(0.82±0.29),FAC(30±9),CT测量右室舒张末期内径(RVd)(45±7)mm,舒张末期面积(2484±596)mm2,Cobb角与RHC—SV具有不同程度中度负性相关;CMRI—EF、RVd、Cobb角与右心做工指数具有负性中度相关。结论MRI-EF是评价PAH患者右心功能最为有效的指标。总体而言MRI评估右心功能的价值最高,其次是MDCT,最后是UCG。Objective To compare the value of cardiac MRI (CMRI), ultrasonic cardiogram (UCG), muhidetector CT (MDCT) in assessing right ventricular function (RV) in patients with PAH. Methods A total of 31 consecutive patients with PAH (17 males and 14 females,55 ± 12 years) in Beijing Chao-Yang Hospital from August 2012 to February 2014 were prospectively enrolled. All patients underwent CMRI to get parameters including right ventricular end-systolic volume ( ESV), end-diastolic dimension (EDV), stroke volume (SV), ejection fraction (EF), ventricular mass index (VMI). UCG parameters included Tei index, RV fractional area change (FAC), ESV, EDV. MDCT parameters included right/left ventricular internal diameter (RVd/LVd) , right/left ventricular diastole maximum area ( RVa/ LVa) , Cobb angle. These parameters obtained by MRI, UCG and MDCT were correlated with those of RHC respectively by Spearman or Pearson correlation analysis. Results Six minutes walk distance had moderate negative correlation with CMRI-EF ( 40 ± 9 ), VMI 44 - 115 ( 71 ± 20 ) g/m2, Cobb angle ( 67 ° ± 12 ° ) ; RHC- SV had moderate negative correlation with CMRI-SV (57± 21 ) ml, EF, VMI, UCG-EF (41 ±14 ), Tei (0. 82 ±0. 29) ,FAC(30 ±9) ,RVd(45 +7) mm,RVa(2 484 ±596) mm2 ,Cobb angle ;Right cardiac work index had moderate negative correlation with CMRI-EF, RVd and Cobb angle. Conclusions MRI-EF is the best parameter to reflect RV function. CMRI is the optimal method to assess RV function, and then is the MDCT and the last is UCG.

关 键 词:高血压 肺性 磁共振成像 超声心动描记术 体层摄影术 X线计算机 

分 类 号:R544.1[医药卫生—心血管疾病]

 

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