职业接触铟工人血和尿中铟的检测  

Determination of indium in the blood and urine of workers exposed to indium

作　　者：张爱华[1] 董明[1] 林怡然 罗晓婷[1] 李添娣 徐小作[3] ZHANG Aihua1,DONG Ming1,LIN Yiran2,LUO Xiaoting1,LI Tiandi2,XU Xiaozuo3(1. Guangdong Province Prevention and treatment Center for occupational diseases,Guangzhou,Guangdong 510300, China; 2. Shenzhen prevention and Treatment Center for Occupational Disease,Shenzhen,Guangdong 518020,China; 3. Bao＇an District Center for Disease Control and Prevention of Shenzhen , Shenzhen , Guangdong 518101, China)

机构地区：[1]广东省职业病防治院,广东广州510300 [2]深圳市职业病防治院,广东深圳518020 [3]深圳市宝安区疾病预防控制中心,广东深圳518101

出　　处：《职业卫生与应急救援》2018年第5期445-448,共4页Occupational Health and Emergency Rescue

基　　金：广东省职业病防治重点实验室(2017B030314152);广东省医学科研基金项目(A2015580;A2016122)

摘　　要：[目的]建立血和尿中铟(In)的检测方法,评估职业接触工人In的接触水平。[方法]血样和尿样用体积分数0.1%的硝酸+体积分数0.02%的曲拉通溶液将原体积稀释至10倍后,采用工作曲线法定量,利用电感耦合等离子体质谱(ICP-MS)法测定血和尿样中In的质量浓度,并用该法对某液晶屏生产企业的82名接触In工人血和尿样中In进行检测。[结果]血和尿中In在选定范围内均具有良好的线性关系,相关系数大于0.999,血和尿中In检出限分别为0.014 5μg/L和0.005 1μg/L,最低检出的质量浓度分别为0.145μg/L和0.051μg/L,血和尿中In的加标回收率分别为98.3%～103.2%和95.2%～100.5%,检测的批内精密度分别为1.11%～2.05%和1.02%～1.99%,批间精密度分别为2.08%～3.99%和1.14%～1.82%。82名工人尿中In的质量浓度均低于最低检出浓度,血中In的质量浓度为<0.145～1.730μg/L。[结论]建立的方法有检出限低、灵敏度高、精密度好等优点,可用于In接触工人血和尿中In的检测。[Objective] To establish a determination method for indium in blood and urine. [Methods] Blood and urine were diluted with the solution 0.1% HNO3＋ 0.02% Trion X-100 and detected by ICP-MS. The working curve method was applied for the quantitative determination. The indium in the blood and urine of 82 workers exposed to indium in a LCD manufacturing enterprise was detected with this method. [Results] The linear relationship in the selected range was good and the related coefficient was greater than 0.999. The detection of limit for the blood and urine were 0.014 5 μg/L and 0.005 1 μg/L,respectively. The minimum detectable analytical concentrations were 0.145 μg/L in blood and 0.051 μg/L in urine. The recovery rate for blood and urine was 98.3%-103.2% and 95.2-100.5%,respectively. The relative standard deviation in batch for blood and urine were 1.11%-2.05% and 1.02%-1.99%,and the relative standard deviation between batch for blood and urine were2.08%-3.99% and 1.14%-1.82%,respectively. Indium was not detected in the urine of those workers exposed to indium and the concentration of indium in the blood was 0.145-1.730 μg/L among them. [Conclusion] This methodology has the advantages of low detect limit,high sensitivity and good precision. It can be used in biological monitoring of workers exposed to indium.

关 键 词：铟 血 尿 电感耦合等离子体质谱 液晶屏生产 

分 类 号：R135[医药卫生—劳动卫生]