几丁质酶-3样蛋白-1与冠心病患者冠脉病变狭窄程度的相关性分析  

Correlation between serum chitinase 3 like 1(YKL-40) level and severity of coronary artery stenosis in patients with coronary heart disease

作　　者：李珍珍[1] 李倩[2] 荆晶[1] 辜小芳[1] 李玉颖 贾倩[3,4] LI Zhenzhen;LI Qian;JING Jing;GU Xiaofang;LI Yuying;JIA Qian(Department of Cardiology,Chinese PLA General Hospital,Beijing 100853,China;Department of Internal Medicine,General Hospital of Xingtai Mining Industry,Jizhong Energy Company,Xingtai 054000,Hebei Province,China;Lab of Translational Medicine,Chinese PLA General Hospital,Beijing 100853,China;Beijing Key Laboratory of Chronic Heart Failure Precious Medicine,Beiiinz 100853,China)

机构地区：[1]解放军总医院心血管内科心脏介入中心,北京100853 [2]冀中能源邢台矿业集团总医院内三科,河北邢台054000 [3]解放军总医院转化医学实验室,北京100853 [4]慢性心衰精准医学北京市重点实验室,北京100853

出　　处：《解放军医学院学报》2018年第10期853-856,共4页Academic Journal of Chinese PLA Medical School

摘　　要：目的通过检测几丁质酶-3样蛋白-1(YKL-40)的水平,探讨该新型生物标记物与冠心病患者冠脉狭窄程度的关联。方法纳入2015年1月1日-2017年10月1日于解放军总医院心血管内科行冠状动脉造影诊断为冠心病的患者200例,测定所有患者YKL-40的水平,并对所有患者进行Syntax评分及定量冠状动脉造影分析以判断冠脉狭窄严重程度。结果 Syntax评分低分组、中分组、高分组患者YKL-40水平分别为(136.18±14.00) mmol/L、(158.36±12.39) mmol/L、(181.18±12.94) mmol/L;此外,随冠脉狭窄程度增加,YKL-40水平呈升高趋势,YKL-40水平与冠脉狭窄程度呈正相关(r=0.808,P <0.05)。结论冠心病患者YKL-40水平与冠脉病变狭窄程度正相关,YKL-40可作为评估冠脉狭窄程度的生物标记物。Objective To investigate the correlation between serum chitinase 3 like 1（YKL-40） and the severity of atherosclerotic plaque in patients with coronary heart disease（CHD）. Methods Two hundred consecutive patients with CHD who underwent coronary angiography in the cardiology department of Chinese PLA General Hospital were recruited from January 1, 2015 to October 1, 2017. Serum YKL-40 was assessed in all patients. Meanwhile, Syntax score and quantitative coronary angiography were used to measure the severity of coronary stenosis. Results The YKL-40 level of low, moderate, high Syntax score group was（136.18±14.00） mmol/L,（158.36±12.39） mmol/L,（181.18±12.94） mmol/L, respectively. The level of YKL-40 increased with the severity of atherosclerotic plaque. Pearson correlation test showed that the level of YKL-40 was positively correlated with the degree of coronary stenosis（r=0.808, P〈0.05）. Conclusion This study shows that the level of YKL-40 in patients with coronary heart disease is correlated with the degree of stenosis of atherosclerotic plaque. YKL-40 can be used as a biomarker to evaluate the degree of coronary stenosis.

关 键 词：几丁质酶-3样蛋白-1 冠状动脉粥样硬化 定量冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]