复方氟康唑凝胶对耐氟康唑假丝酵母菌的抗菌效果研究  

Antibacterial effect of fluconazole resistant Candida by using Compound Fluconazole Gel

作　　者：高新富[1] 邢树礼[1] 赵永德[1] 李保院[1] 姜宏[1] 孙绍伟[1] 宋征[1] GAO Xinfu;XING Shuli;ZHAO Yongde;Ll Baoyuan;JIANG Hong;SUN Shaowei;SONG Zheng(Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院,山东滨州256603

出　　处：《药学研究》2018年第11期638-641,共4页Journal of Pharmaceutical Research

基　　金：滨州市科技发展计划项目(No.2014ZC0141);滨州市科技发展计划项目(No.2014ZC0310);山东省医药卫生科技发展计划项目(No.2016WS0050);山东省医药卫生科技发展计划项目(No.2017WS233)

摘　　要：目的验证复方氟康唑凝胶对耐氟康唑假丝酵母菌的抗菌效果。方法选用琼脂扩散法,比较复方氟康唑凝胶与氟康唑凝胶对耐氟康唑假丝酵母菌的体外抑菌效果;通过感染耐氟康唑假丝酵母菌大鼠治疗试验,比较复方氟康唑凝胶与氟康唑凝胶治疗效果。结果复方氟康唑凝胶抑菌圈直径(18.55±0.03) mm (n=20),氟康唑凝胶抑菌圈直径(7.12±0.01) mm (n=20),差异具有统计学意义(P<0.05);复方氟康唑凝胶治疗感染耐氟康唑假丝酵母菌大鼠15 d的转阴率为80%,氟康唑凝胶为40%,差异具有统计学意义(P<0.05,n=15);复方氟康唑凝胶抑制阴道灌洗液炎性细胞因子水平能力、减轻病变损伤程度明显高于氟康唑凝胶(P<0.05,n=15)。结论复方氟康唑凝胶对耐氟康唑假丝酵母菌的抗菌效果肯定,较氟康唑凝胶具有优势。Objective To investigate antibacterial effects of fluconazole resistant Candida by using Compound Fluconazole Gel. Methods Compared the antibacterial effects in vitro between Compound Fluconazole Gel and Fluconazole Gel to fluconazole resistant Candida by using the agar diffusion method; through treatment trial of rats infected by fluconazole resistant Candida ,to compare the treatment effect between Compound Fluconazole Gel and Fluconazole Gel. Results The inhibition zone diameters was about （18.55±0.03）mm （ n =20）,when fluconazole resistant Candida we retested to Compound Fluconazole Gel,the inhibition zone diameters was about （7.12±0.01）mm （ n =20）,when fluconazole resistant Candida we retested to Fluconazole Gel,two sets of data between a statistically significant difference（ P 〈0.05）; the negative transformation rate of rats infected by fluconazole resistant Candida in Compound Fluconazole Gel group within 15 days was 80%,and 40% in Fluconazole Gel group,two groups of the negative transformation rate compared statistically significant difference （ P 〈0.05, n =15）;the cytokines levels in cervical-vaginal lavage solution and the degree of lesion damage in Compound Fluconazole Gel group,was significantly higher than the Fluconazole Gel group（ P 〈0.05, n =15）. Conclusion The effects of Compound Fluconazole Gel on treating fluconazole resistant Candida is definite,this drug has a big advantage over Fluconazole Gel.

关 键 词：复方氟康唑凝胶 氟康唑 黄芩苷 假丝酵母菌 耐药性 抑菌效果 

分 类 号：R978.5[医药卫生—药品]