原发性与继发性血小板增多症的实验室检查特征比较  

Comparison of laboratory findings between essential thrombocythemia and secondary thrombocythemia

作　　者：王青[1] 赵文军[2] 林爱芬[3] 郑瑞[1] WANG Qing;ZHAO Wenjun;LIN Aifen(Center Laboratory,Taizhou Hospital of Zhejiang Province,Taizhou 317000,China)

机构地区：[1]浙江省台州医院中心实验室,317000 [2]浙江省台州医院血管外科,317000 [3]浙江省台州医院组织标本库,317000

出　　处：《浙江医学》2018年第22期2459-2461,共3页Zhejiang Medical Journal

基　　金：国家科技资料共享服务平台计划项目(YCZYPT[2017]02)

摘　　要：目的通过比较原发性血小板增多症(ET)与继发性血小板增多症(ST)患者的血液学检查结果及JAK2酪氨酸激酶基因(JAK2V617F)检测结果,分析两者的实验室检查特征。方法回顾性选取ET患者162例、ST患者88例。分析并比较ET患者与ST患者治疗开始前的血WBC、RBC、Hb、PLT及血小板分布宽度(PDW)检测结果;观察患者血栓栓塞性疾病患病情况。结果 ET患者WBC、RBC、Hb、PLT、PDW水平均高于ST患者(均P<0.05)。JAK2V617F阳性ET患者WBC、RBC、Hb、PDW水平均高于JAK2V617F阴性ET患者(均P<0.05)。JAK2V617F阳性ET患者WBC、RBC、Hb、PLT、PDW水平均高于ST患者(均P<0.05)。JAK2V617F阴性ET患者的Hb、PLT、PDW水平均高于ST患者(均P<0.05)。ET患者血栓栓塞性疾病患病率高于ST患者(P<0.05)。结论 Hb、PLT、PDW等实验室检查结果可作为初步鉴别JAK2V617F阴性ET与ST的参考指标,早期诊断和治疗ET有助于预防血栓栓塞性疾病的发生、发展。Objective To compare the results of hematological examination and JAK2 tyrosine kinase gene（JAK2V617F） detection in patients with essential thrombocythemia（ET） and secondary thrombocythemia（ST）. Methods The clinical data of 162 patients with ET and 88 patients with ST were retrospectively reviewed. Blood WBC, RBC, Hb, PLT and platelet distribution width （PDW） were analyzed in ET patients and ST patients before treatment, and the prevalence of thromboembolic diseases was observed. Results The levels of WBC, RBC, Hb, PLT and PDW in ET patients were higher than those in ST patients（P〈0.05）. The levels of WBC, RBC, Hb and PDW in JAK2V617F positive ET patients were higher than those in JAK2V617F negative ET patients（all P〈0.05）. The levels of WBC, RBC, Hb, PLT and PDW in both JAK2V617F positive and negative ET patients were higher than those in ST patients（all P〈0.05）. The prevalence of thromboembolic disease in ET patients was higher than that in ST patients（P〈0.05）. Conclusion Hb, PLT, PDW and other parameters can be used as reference index for differentiating JAK2V617F mutation negative ET and ST, early diagnosis and treatment of ET may be beneficial for preventing the occurrence and development of thromboembolic disease.

关 键 词：原发性血小板增多症 继发性血小板增多症 血栓栓塞性疾病 

分 类 号：R558.3[医药卫生—血液循环系统疾病] R446.11[医药卫生—内科学]