具有抗菌功能的泌尿系统人工管道的研究进展  

Research Progress on Artificial Conduits for Urological Application with Antibacterial Function

作　　者：高立恒 邹婷[1] 王一惟[2] 达骏[2] 王李天牧 王富军[1] 王璐[1] GAO Liheng;ZOU Ting;WANG Yiwei;DA Jun;WANG Litianmu;WANG Fujun;WANG Lu(Key Laboratory of Textile Science and Technology,Ministry of Education,College of Textiles,Donghua University,Shanghai,201620;Shanghai Ninth People＇s Hospital,Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,201620)

机构地区：[1]东华大学纺织学院纺织面料技术教育部重点实验室,上海市201620 [2]上海交通大学医学院附属第九人民医院,上海市201620

出　　处：《中国医疗器械杂志》2018年第6期434-436,452,共4页Chinese Journal of Medical Instrumentation

基　　金：教育部纺织生物医用材料创新引智基地111计划(B07024);上海交通大学医学院转化项目(TM201719);2018中央高校基本科研业务费项目;东华大学大学生创新基金

摘　　要：泌尿系统人工管道是泌尿外科常用的引流工具,主要包括输尿管支架管和导尿管。由于人工管道的植入时间较长,且尿液中细菌种类繁多,易形成生物膜并引发尿路感染。该文根据导尿管相关尿路感染的发生机理,从病原学角度阐述了尿液环境的特点和生物膜的形成条件。并从抗菌剂和抗菌整理方法两方面,介绍了适用于输尿管支架管和导尿管的抗菌策略,且综述了其优缺点。Artificial conduits, including areteral stents and catheters, are used widely as drainage tools in the urinary system. However, various bacteria in the urine and long duration of insertion can arouse the biofilm formation on the pipeline surface, which calls for effective antibacterial strategy. In this article, the mechanism of Catheter Associated Urinary Tract Infections （CAUTI） is explained from the perspective of etiology. Then, the biofilm formation conditions and the features of urine are analyzed, the antibacterial agents and approaches suitable for ureteral stents and catheters are introduced and their pros and cons are discussed respectively.

关 键 词：输尿管支架管 导尿管 导尿管相关尿路感染(CAUTI) 生物膜 抗菌剂 抗菌方法 

分 类 号：R197.39[医药卫生—卫生事业管理]