杞菊地黄丸加减治疗早期乳腺癌术后服用芳香化酶抑制剂致高血脂症的临床研究  

Clinical study on the treatment with Qijudihuang pill for hyperlipidemia caused by aromatase inhibitors after breast cancer surgery

作　　者：张晓清[1] 任晓梅[1] 卞卫和[1] 姚昶[1] 应语[1] 许岩磊[1] ZHANG Xiaoqing;REN Xiaomei;BIAN Weihe;YAO Chang;YING Yu;XU Yanlei(Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210000,Jiangsu,China)

机构地区：[1]江苏省中医院,江苏南京210000

出　　处：《现代中西医结合杂志》2018年第35期3912-3915,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨杞菊地黄丸加减治疗早期乳腺癌术后服用芳香化酶抑制剂(AI)致高血脂症的临床疗效。方法选择正在服用AI且并发高血脂症的绝经后早期乳腺癌术后患者60例,随机分为治疗组30例和对照组30例。对照组口服阿托伐他汀钙片10 mg每日1次,治疗组在口服阿托伐他汀钙片基础上给予杞菊地黄丸加减治疗。2组均以1个月为1个疗程,共治疗2个疗程。结果 2组治疗后TG、TC、LDL-C及HDL-C水平比较差异均无统计学意义(P均> 0. 05)。治疗组治疗后血脂水平改善的总有效率为86. 7%,对照组总有效率为80. 0%,2组比较差异无统计学意义(P> 0. 05)。2组治疗后中医证候评分均明显下降(P均<0. 05),且治疗组中医证候评分较对照组下降程度更明显(P <0. 05)。治疗组治疗后中医证候总有效率为90. 0%,明显高于对照组的46. 7%(P <0. 05)。结论在服用阿托伐他汀钙片的基础上加服杞菊地黄丸加减治疗乳腺癌术后服用AI所致高血脂症患者,可明显降低患者的血脂水平,改善患者的中医证候,提高患者的生活质量。Objective It is to investigate the clinical efficacy of Qijudihuang pill in the treatment of hyperlipidemia caused by aromatase inhibitor （AI） after breast cancer surgery. Methods A total of 60 postmenopausal patients with hyperlipidemia caused by AI after early breast cancer surgery were randomly divide into treatment group and control group, each group had 30 cases. The control group received oral atorvastatin calcium tablets 10 mg once daily. On the basis of oral atorvastatin calcium tablets, the treatment group was treated with Qijudihuang pill. One month was a course of treatment, both groups were treated for a total of two courses. The improvement of blood fat and traditional Chinese medicine （TCM） syndrome were compared between the two groups after treatment. Results There was no significant difference in the levels of TG, TC, LDL-C and HDL-C between the two groups after treatment（ P 〉0.05）. The total effective rate of improvement of blood lipid was 80.0% in the control group and 86.7% in the treatment group, the difference was not significant between the two groups （ P 〉0.05）. The TCM syndrome symptom scores of the two group were significantly decreased after treatment in the two groups （ P 〈0.05）, and the decrease in the treatment group was more significant than that in the control group （ P 〈0.05）. The total effective rate of TCM syndrome in the treatment group was significantly higher than that in the control group （ P 〈0.05）. Conclusion The treatment with Qijudihuang pill basen on atorvastatin calcium tablet can significantly reduce blood lipid, improve the patient’s TCM symptom and quality of life in the patients hyperlipidemia caused by AI after early breast cancer surgery.

关 键 词：杞菊地黄丸 乳腺癌 芳香化酶抑制剂 高血脂症 

分 类 号：R589.2[医药卫生—内分泌]