噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病与阻塞性睡眠呼吸暂停重叠综合征36例  

Effect of Tiotropium Bromide Powder Inhalation in Treatment of 36 Cases of COPD-OSAHS Overlap Syndrome

作　　者：江城[1] 张念[1] 张燕[1] Cheng JIANG;Nian ZHANG;Yan ZHANG(General Medicine,Wuhan First Hospital,Wuhan 430022,China)

机构地区：[1]武汉市第一医院综合内科,武汉430022

出　　处：《医药导报》2018年第12期1474-1477,共4页Herald of Medicine

基　　金：湖北省卫计委科研项目(WJ2015MB238);武汉市卫计委项目(WZ14B04);武汉市卫计委项目(WX14B32)

摘　　要：目的观察吸入噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病与阻塞性睡眠呼吸暂停(COPD-OSAHS)重叠综合征患者的肺功能、血气分析的变化,了解其临床意义。方法采用随机对照研究69例COPD-OSAHS重叠综合征患者,将患者分为治疗组(入组44例,完成36例)及对照组(入组39例,完成33例)。治疗组在常规治疗基础上加用噻托溴铵吸入剂(每天1粒,规格:每粒18μg),对照组使用常规治疗。总观察时间12周,观察治疗后患者PaO_2、PaCO_2、FEV1%pre、FEV1/FVC有无差异。结果治疗后治疗组PaO_2(10.05±1.15) k Pa、PaCO_2(5.85±0.90) k Pa、FEV1%pre(52.73±6.72)%、FEV1/FVC(56.52±4.27)%及对照组PaO_2(9.26±1.14) kPa、PaCO_2(5.98±1.00) k Pa、FEV1%pre (48. 12±6. 45)%、FEV1/FVC(54. 29±8.18)%与治疗前比较,差异有统计学意义(P<0.05);比较两组各项指标治疗前后的差值,其差异有统计学意义(P<0.05)。结论吸入噻托溴铵可以改善COPD-OSAHS重叠综合征患者的低氧血症、二氧化碳潴留、高碳酸血症以及肺功能。Objective To observe the changes of pulmonary function and blood gas analysis in patients with chronic obstructive pulmonary disease-obstructive sleep apnea-hypopnea syndrome （COPD-OSAHS） overlap syndrome by treatment with tiotropium bromide powder inhalation, and to understand its clinical significance. Methods A randomized controlled study was conducted in 69 COPD-OSAHS overlap syndrome patients.The patients were divided into the treatment group （44 cases in the group, 36 cases completed） and the control group （39 cases in the group, 32 cases completed）.The treatment group was given the conventional therapy and tiotropium bromide inhalation （1 pill per day, 18 μg/pill）, and the control group was only given the conventional therapy.The total observation time was 12 weeks, the changes of PaO2, PaCO2, FEV1% pre and FEV1/FVC were observed after treatment. Results After treatment, PaO2 （10.05±1.15） kPa, PaCO2 （5.85±0.90） kPa, FEV1pre （52.73±6.72） %, FEV1/FVC （56.52±4.27） % in the treatment group and PaO2 （9.26±1.14） kPa, PaCO2 （5.98±1.00） kPa, FEV1 pre （48.12±6.45） %, FEV1/FVC （54.29±8.18） % in the control group were significantly different from those before the treatment （P〈0.05）.The difference values of the indexes before and after the treatment were significantly different between the two groups （P〈0.05）. Conclusion Inhalation of thiotitronium bromide can improve hypoxemia, carbon dioxide retention, hypercapnia and pulmonary function of the patients with COPD-OSAHS overlap syndrome.

关 键 词：噻托溴铵 肺疾病 阻塞性 慢性 综合征 睡眠呼吸暂停 阻塞性 综合征 重叠 肺功能 血气分析 

分 类 号：R974.3[医药卫生—药品] R563.5[医药卫生—药学]