药学干预对骨科围手术期注射用质子泵抑制剂合理使用的效果评价  

Effect of Pharmacy Interventions on the Rational Use of Proton Pump Inhibitors Injections in Perioperative Period of Orthopedic Surgery

作　　者：刘慧敏 王珊 李华 李聪 熊琳 田先地 戢太阳 邵将 陈富超 Huimin LIU;Shan WANG;Hua LI;Cong LI;Lin XIONG;Xiandi TIAN;Taiyang JI;Jiang SHAO;Fuchao CHEN(Department of Pharmacy,Dongfeng Hospital Affiliated to Hubei University of Medicine,Shiyan 442008,China)

机构地区：[1]湖北医药学院附属东风医院药学部,十堰442008

出　　处：《医药导报》2018年第12期1509-1512,共4页Herald of Medicine

基　　金：十堰市科学技术研究与开发项目(14Y49)

摘　　要：目的评价药学干预促进注射用质子泵抑制药(PPIs)在骨科围手术期合理预防使用的效果。方法以临床药师为主体,对骨科手术患者实行注射用PPIs预防使用监控和干预,对干预前阶段(2017年4月)、干预第1阶段(2017年5月)、干预第2阶段(2017年6月)、干预第3阶段(2017年7月)的PPIs使用率、有指征预防使用率、平均使用频次、平均日剂量和平均疗程进行回顾性统计分析,同时比较注射用PPIs的人均消耗金额、与总药费以及住院费用的占比。结果干预后注射用PPIs的使用率由65.85%降至11.72%,平均疗程由(6.60±5.41) d缩短至(2.88±2.03) d,注射用PPIs人均消耗金额由(247.74±234.79)元降至(126.30±131.78)元,有适应证的用药比例由37.96%提高至76.47%。结论运用药学干预模式可进一步规范骨科手术患者围手术期注射用PPIs的预防使用,并降低患者的经济负担。Objective To evaluate the effect of pharmacy intervention in promoting the use of proton pump inhibitors （PPIs） injection in the perioperative period of orthopedic surgery. Methods Clinical pharmacists monitored and interfered with the use of PPIs injection of patients with orthopedic surgery.The intervention process was divided into four stages： the pre-intervention stage （April 2017）, the first stage （May 2017）, the second stage （June 2017） and the third stage （July 2017）.PPIs utilization rate, rate of medication for prevention with indications, mean frequency of use, mean daily dose, and mean duration of treatment were retrospectively statistically analyzed.After intervention course, the per capita cost of PPIs injections, the proportion of it to total cost of medical expenses and hospitalization were compared with those of pre-intervention. Results After the intervention, the utilization rate of PPIs was reduced from 65.85% to 11.72%, the average course of treatment was shortened from （6.60±5.41） days to （2.88±2.03） days.The per capita cost of PPIs decreased from （247.74±234.79） to （126.30±131.78） yuan , and the rate of medication for indications increased from 37.96% to 76.47%. Conclusion The mode of drug intervention can further regulate the prevention and treatment of PPIs in perioperative period of orthopedic surgery patients and reduce the economic burden of patients.

关 键 词：质子泵抑制药 预防使用 药学干预 手术 骨科 围手术期 

分 类 号：R975.6[医药卫生—药品] R969.3[医药卫生—药学]