自拟6542方治疗绝经后骨质疏松症临床研究  

Clinical Study on Self-made 6542 Prescription in Treating Postmenopausal Osteoporosis

作　　者：张亚嘉 胡红娟[1] 何渝煦[1] 彭强丽[1] ZHANG Ya-jia;HU Hong-juan;HE Yu-xu;PENG Qiang-li(Yunnan College of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南省中医医院,云南昆明650021

出　　处：《中国中医药信息杂志》2018年第12期11-14,共4页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的探讨自拟6542方治疗绝经后骨质疏松症(PMOP)临床疗效。方法采用随机数字表法将146例PMOP肝肾阴虚证患者随机分为观察组和对照组各73例。对照组予阿法骨化醇胶丸,每次0.25μg,每日2次,口服;钙尔奇D3咀嚼片,每次600 mg,每日1次,嚼服。观察组在对照组基础上予自拟6542方,每次150 mL,每日3次,口服。2组均4周为1个疗程,连续治疗6个疗程。评价2组临床疗效及中医疗效,检测治疗前后患者血清骨碱性磷酸酶(BALP)、抗酒石酸酸性磷酸酶-5b(TRACP-5b)、前列腺素E2(PGE2)及骨密度水平。结果观察组中医疗效总有效率为93.2%(68/73),对照组为68.5%(50/73),观察组明显优于对照组(P<0.01)。观察组临床疗效总有效率为84.9%(62/73),对照组为69.9%(51/73),观察组明显优于对照组(P<0.05)。与本组治疗前比较,观察组治疗3、6个疗程及对照组治疗6个疗程,L2～4、左股骨颈及左股骨大转子骨密度明显升高(P<0.05)。治疗6个疗程,观察组L2～4、左股骨颈及左股骨大转子骨密度明显高于对照组(P<0.01)。与本组治疗前比较,观察组治疗6个疗程PGE2、TRACP-5b、BALP水平明显改善(P<0.05),对照组治疗6个疗程TRACP-5b、BALP水平明显改善(P<0.05)。治疗6个疗程,观察组PGE2、TRACP-5b水平明显优于对照组(P<0.01)。结论自拟6542方治疗PMOP疗效满意,可改善骨密度及骨代谢生化指标。Objective To explore the clinical efficacy of self-made 6542 prescription for postmenopausal osteoporosis. Methods Totally 146 postmenopausal osteoporosis patients with liver-kidney yin deficiency syndrome were divided into the observation group and the control group through random number table method, with 73 cases in each group. The control group was given Alfa calcidol soft capsule, 0.25 μg per time, twice a day, orally; Calc D3, 600 mg per time, once a day, orally. The observation group was given self-made 6542 prescription on the basis of the control group, 150 mL per time, three times a day, orally. Four weeks were one treatment course for both groups for six treatment courses. Clinical efficacy and TCM efficacy of both groups, serum bone alkaline phosphatase （BALP）, tartrate-resistant acid phosphatase-5b （TRACP-5b）, prostaglandin E2 （PGE2） and bone mineral density before and after treatment were evaluated. Results The total effective rate of TCM efficacy in the observation group was 93.2% （68/73）, and 68.5% （50/73） in the control group. The observation group was significantly better than the control group （P〈0.01）. The total effective rate was 84.9% （62/73） in the observation group and 69.9% （51/73） in the control group. The observation group was significantly better than the control group （P〈0.05）. Compared with before treatment, L2-4, left femoral neck and left femur trochanter bone mineral density increased significantly in the observation group when treated 3, 6 courses and the control group for 6 courses （P〈0.05）. The bone mineral density of the L2-4, left femoral neck and left femur greater trochanter were significantly higher in the observation group than those in the control group after six treatment courses （P〈0.01）. Compared with before treatment, the levels of PGE2, TRACP-5b and BALP in the observation group were significantly improved （P〈0.05）, and the levels of TRACP-5b and BALP in the control group were significantly improved after si

关 键 词：绝经后骨质疏松 肝肾阴虚证 自拟6542方 

分 类 号：R274.915.5[医药卫生—中西医结合]