Using organotypic hippocampal slice cultures to gain insight into mechanisms responsible for the neuroprotective effects of meloxicam: a role for gamma aminobutyric and endoplasmic reticulum stress  

作　　者：Elisa Landucci Irene L.Llorente Berta Anuncibay-Soto Domenico E.Pellegrini-Giampietro Arsenio Fernández-López 

机构地区：[1]Sezione di Farmacologia Clinica e Oncologia, Dipartimento di Scienze della Salute,Università di Firenze [2]Department of Neurology, David Geffen School of Medicine, University of California [3]área de Biología Celular, Instituto de Biomedicina,Universidad de León [4]Neural Therapies SL, Edificio Institutos de Investigación

出　　处：《Neural Regeneration Research》2019年第1期65-66,共2页中国神经再生研究（英文版）

基　　金：supported by the Spanish Ministerio de Economia y Competitividad(MINECO);co-financed with FEDER funds ‘‘una manera de hacer Europa"(reference RTC-2015-4094-1);Junta de Castilla y León(reference LE025P17);Neural Therapies SL(reference NT-Dev01)

摘　　要：This perspective aims to put into context the recent article by Landucci et al.(2018)on mechanisms involved in the neuroprotective effects of meloxicam on an organotypic hippocampal slice cultures(OHSCs)model.In vitro cell cultures are the main method for studying large quantities of homogeneous cells in an isolated environment.Thus,the use of primary dissociated neuron,astrocyte,oligodendrocyte,microglia,or endothelial cell cultures has become a standardThis perspective aims to put into context the recent article by Landuc- ci et al. （2018） on mechanisms involved in the neuroprotective effects of meloxicam on an organotypic hippocampal slice cultures （OHSCs） model. In vitro cell cultures are the main method for studying large quantities of homogeneous cells in an isolated environment.

关 键 词：GAMMA 文化 海马 机制 应力 蜂窝 环境学习 胃 

分 类 号：R96[医药卫生—药理学]