β1、β3肾上腺素受体自身抗体与老年慢性心力衰竭恶性心律失常的相关性  

Correlation of β1,β3 Adrenergic Receptor Autoantibodies and Malignant Arrhythmia of Elderly Chronic Heart Failure Patients

作　　者：李诗洋[1] 席小青[1] 柳达[1] 罗文利[1] 王丽[2] LI Shi-yang;XI Xiao-qing;LIU Da;LUO Wendi;WANG Li(Department of Geriatrics,Shihezi University Medicine College the First Affiliated Hospital,Shihezi Xinjiang 832008;Department of Cardiology,Shihezi University Medical College the First Affiliated Hospital,Shihezi Xinjiang 832008）.)

机构地区：[1]石河子大学医学院第一附属医院老年科,新疆石河子832008 [2]石河子大学医学院第一附属医院心内科,新疆石河子832008

出　　处：《世界最新医学信息文摘》2018年第26期6-7,共2页World Latest Medicine Information Electronic Version

基　　金：2015年兵团社会发展科技攻关与成果转化计划课题(2015AD030)

摘　　要：目的老年慢性心力衰竭患者中进行β1、β3肾上腺素能受体自身抗体的检测,分析与恶性心律失常的相关性。方法连续纳入2012年至2016年入院的老年慢性心力衰竭患者305例,以24h动态心电图结果分为恶性心律失常组(113例)和非恶性心律失常组(192例),统计两组β1-AA、β3-AA水平,并logistic回归分析恶性心律失常的危险因素。结果 (1)恶性心律失常组β1-AA、β3-AA均高于对照组,P<0.05。(2)左室射血分数、NT-proBNP、β3-AA为慢性心力衰竭恶性心律失常的相关因素(P<0.05)。结论β3肾上腺素受体自身抗体可能参与了恶性心律失常的发生的病理生理过程。Objective to detect beta 1 and beta 3 adrenergic receptor autoantibodies of elderly chronic heart failure patients, and analyze its correlation with malignant arrhythmia. Methods include 305 cases elderly chronic heart failure patients in our hospital from 2012 to 2016 continuously, based on results of dynamic 24h ECG, divide them into malignant arrhythmia group（113 cases） and non malignant arrhythmia group（192 cases）, carry on statistics of beta 1-AA and beta 3-AA level of two groups, and analyze risk factors of malignant arrhythmia by logistic regression. Results（1） beta 1-AA and beta 3-AA level of malignant arrhythmia group was higher than control group, P〈0.05.（2） Left ventricular ejection fraction, NT-pro BNP, and beta 3-AA was related factors of malignant arrhythmia in chronic heart failure,（P〈0.05）. Conclusion beta 3 adrenergic receptor autoantibody may be involved in pathophysiological process of occurrence of malignant arrhythmia.

关 键 词：心力衰竭 自身抗体 恶性心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]