广东紫珠叶乙酸乙酯部位的化学成分研究  

Ethyl Acetate-soluble Chemical Constituents from the Leaves of Callicarpa kwangtungensis Chun

作　　者：毕红玉 付辉政 周志强 戴冕 冯童童 王栋 BI Hong-yu;FU Hui-zheng;ZHOU Zhi-qiang;DAI Mian;FENG Tong-tong;WANG Dong(Jiangxi University of Traditional Chinese Medicine,Nanehang 330006,China;Jiangxi Provincial Institute for Drug Control,Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality,Nanehang 330029,China;Food Inspection and Testing Institute of Jiangxi Province,Jiangxi National Fruit and Vegetable Products and Processed Food Quality Supervision and Inspection Center,Nanehang 330001,China)

机构地区：[1]江西中医药大学,南昌330006 [2]江西省药品检验检测研究院江西省药品与医疗器械质量工程技术研究中心,南昌330029 [3]江西省食品检验检测研究院江西国家果蔬产品及加工食品质量监督检验中心,南昌330001

出　　处：《中国药学杂志》2018年第21期1810-1814,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81460589)

摘　　要：目的研究广东紫珠叶乙酸乙酯部位的化学成分。方法利用硅胶、Sephadex LH-20、ODS、MPLC等柱色谱方法进行化合物的分离纯化,根据化合物的理化性质、波谱方法进行结构鉴定。结果从广东紫珠叶乙酸乙酯部位分离得到13个化合物,分别为:5,7,2',6'-四羟基黄酮(1)、2,3-dehydrosilychristin(2)、silychristin A(3)、二氢槲皮素(4)、丁香脂素(5)、杜仲树脂酚(6)、(7R,8S)-3,5'-dimethoxy-4',7-epoxy-8,3'-neolignane-5,9,9'-triol(7)、(2S,3R)-methyl-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzofuran-5-carboxylate(8)、curcasinlignan B (9)、香草醛(10)、19α-羟基熊果酸(11)、2α,3β,19α,23-四羟基-齐墩果-12-烯-28-酸(12)和蔷薇酸(13)。结论以上化合物均为首次从广东紫珠中分离得到。OBJECTIVE To study the chemical ethyl acetate-soluble constituents of the leaves of Callicarpa kwangtungensis Chun. METHODS The compounds were isolated and purified by column chromatography using silica gel, Sephadex LH -20, ODS and MPLC. The structures of the compounds were identified according to their physicochemical properties and spectroscopic methods. RESULTS Thirteen compounds were isolated and identified as 5,7,2＇ ,6＇-tetrahydroxyflavone（ 1 ）, 2,3-dehydrosilychristin（2）, silychristin A （ 3 , dihydroquercetin （4）, syringaresinol （ 5 ）, medioresinol （ 6 ）, （ 7R, 8 S） -3,5 ＇-dimethoxy-4＇, 7-epoxy-8,3＇-neolignane -5, 9,9＇-triol （ 7 , （ 2S, 3R ） -methyl-7-hydroxy-2-（ 4-hydroxy-3-methoxyphenyl ） -3-（ hydroxymethyl ） -2,3-dihydrobenzofuran-5-carboxylate （8）, curcasinlignan B （ 9 ）, vanillin （ 10 ）, 19α-hydroxyursolic acid （ 11 ）, 2α, 313,19α, 23-tetrahydroxy-12-ene-28-oleanolic acid （12）, and euscaphic acid（13）. CONCLUSION All these compounds were isolated from this plant for the first time.

关 键 词：广东紫珠 马鞭草科 5 7 2’ 6'-四羟基黄酮 二氢槲皮素 

分 类 号：R284[医药卫生—中药学]