原位自组装多肽在肿瘤和细菌感染诊断及治疗中的研究进展  

Research progress of in situ self-assembling peptides in diagnosis and treatment of tumors and bacterial infections

作　　者：张从柔 黄帆[1] 刘鉴峰[1] 杨丽军[1] ZHANG Cong-rou;HUANG Fan;LIU Jian-feng;YANG Li-jun(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]北京协和医学院&中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《天津医药》2018年第11期1241-1245,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(21708048、51603231、81722026);中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-0222017-I2M-2-00416ZXXYSY00040)

摘　　要：肿瘤和细菌感染严重危害人类健康,因此亟需开发有效的诊疗方法以克服这两类疾病。原位自组装多肽能够特异识别病灶部位某些特异性高表达的物质,靶向性地在病灶部位聚集,并通过自组装形成稳定的纳米结构,从而实现疾病的精确诊断和有效治疗,并降低对正常组织的毒副作用,是一种在疾病诊疗方面应用前景广阔的医用材料。本文就原位自组装多肽在肿瘤和细菌感染的诊断及治疗中的研究进展进行综述。Tumor and bacterial infections are seriously endanger human health. Therefore, it is urgent to develop effective theranostic methods to overcome these two types of diseases. In-situ self-assembling peptides can target to in-situ aggregation of lesions induced by certain specifically high-expressed substances at the lesion site and form stable nanostructures through self-assembly, thereby facilitating the accurate diagnosis and effective therapy of diseases. The therapeutic effect and the reduced toxic side effects on normal tissues make the in-situ self-assembling peptides a kind of medical material with broad application prospects in the diagnosis and treatment of diseases. This article reviews the research progress of in situ self-assembling peptides in the diagnosis and treatment of tumor and bacterial infections.

关 键 词：肿瘤 细菌感染 诊断 治疗 原位自组装多肽 诊疗一体化 

分 类 号：R318.08[医药卫生—生物医学工程]