利培酮对精神分裂症阴性症状治疗的疗效及临床护理  

Efficacy and Clinical Nursing of Risperidone in the Treatment of Negative Symptoms of Schizophrenia

作　　者：戴美珠 周志萍 许美琴 DAI Mei-zhu;ZHOU Zhi-ping;XU Mei-qin(Third People＇s Hospital of fuzhou,Fuzhou Jiangxi 344000,China)

机构地区：[1]抚州市第三医院,江西抚州344000

出　　处：《药品评价》2018年第22期49-52,共4页Drug Evaluation

摘　　要：目的:探讨利培酮治疗精神分裂症阴性症状的疗效及护理干预的意义。方法:选取2016.04—2018.04来我院就诊的152例精神分裂症患者为研究对象,两组患者均给予利培酮进行治疗,根据护理方案的不同,随机分为观察组和对照组,每组76例。比较两组患者的临床疗效、PANSS阴性症状评分、生活质量、治疗依从性、不良反应发生情况。结果:观察组患者的临床有效率为92.11%(70/76),显著高于对照组的69.74%(53/76),差异有统计学意义,P<0.05。治疗前,两组患者PANSS阴性症状评分无显著差异,P>0.05。治疗后,观察组PANSS阴性症状评分为(13.5±1.6),显著低于对照组的(18.4±2.7),差异有统计学意义,P<0.05。治疗前,两组患者SF-36各方面评分无显著差异,P>0.05。治疗后,两组患者SF-36各方面评分均增加,且观察组显著高于对照组,差异有统计学意义,P<0.05。观察组患者治疗依从率为97.37%(74/76),显著高于对照组的69.74%(53/76),差异有统计学意义,P<0.05。观察组不良反应发生率为11.84%(9/76),显著低于对照组的51.32%(39/76),差异有统计学意义,P<0.05。结论:在利培酮治疗精神分裂症的基础上联合综合护理干预,临床疗效较好,且能显著改善阴性症状,提高患者生活质量和治疗依从性,安全性高。Objective： To investigate the efficacy of risperidone in the treatment of negative symptoms of schizophrenia and the significance of nursing intervention. Methods： A total of 152 patients with schizophrenia admitted to our hospital from 2016.04 to 2018.04 were enrolled in the study. Both groups were treated with risperidone. According to different nursing regimens, they were randomly divided into observation group and control group, with 76 cases in each group. The clinical efficacy, PANSS negative symptom score, quality of life, treatment compliance, and adverse reactions were compared between the two groups. Results： The clinical effective rate of the observation group was 92.11% （70/76）, which was significantly higher than that of the control group （69.74% （53/76））. The difference was statistically significant （P〈0.05）. Before treatment, there was no significant difference in PANSS negative symptom score between the two groups （P〉0.05）. After treatment, the PANSS negative symptom score in the observation group was （13.5±1.6）, which was significantly lower than that in the control group （18.4±2.7）, and the difference was statistically significant （P〈0.05）. Before treatment, there was no significant difference in the scores of SF-36 between the two groups （P〉0.05）. After treatment, the scores of SF-36 in all groups increased, and the observation group was significantly higher than the control group, the difference was statistically significant, P〈0.05. The treatment compliance rate of the observation group was 97.37% （74/76）, which was significantly higher than that of the control group （69.74% （53/76））. The difference was statistically significant （P〈0.05）. The incidence of adverse reactions in the observation group was 11.84% （9/76）, which was significantly lower than that in the control group （51.32% （39/76））. The difference was statistically significant （P〈0.05）. Conclusion： Risperidone combined with comprehensive nur

关 键 词：利培酮 精神分裂症 阴性症状 疗效 护理干预 

分 类 号：R971.4[医药卫生—药品]