儿童矮小症485例病因探讨及治疗效果  

Etiology and treatment effect of 485 children with short stature

作　　者：吴韬[1] 杜俊文[1] 张坤[1] 任巧华[1] 郭静霞[1] 周士超 WU Tao;DU Jun-wen;ZHANG Kun;REN Qiao-hua;GUO Jing-xia;ZHOU Shi-chao(Department of Endocrinology,the First Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050011,China)

机构地区：[1]河北省石家庄市第一医院内分泌一科,河北石家庄050011

出　　处：《河北医科大学学报》2018年第12期1384-1388,共5页Journal of Hebei Medical University

基　　金：石家庄市科学技术研究与发展指导计划(161460683)

摘　　要：目的探讨矮小症的病因,并观察重组人生长激素治疗生长激素缺乏症(growth hormone deficiency,GHD)及特发性矮小症(idiopathic short stature,ISS)的疗效。方法将矮小症患儿485例依据病因进行分类。将青春期前的GHD及ISS患儿分别分为重组人生长激素治疗组及对照组,比较治疗前、治疗后3个月及治疗后6个月的身高、生长速度(growth rate,GV)及身高标准差积分(height standard deviation score,HtSDS),比较治疗前及治疗后6个月的骨龄。结果矮小症患儿中ISS最多185例,其次GHD 140例,并发现了罕少疾病。GHD及ISS患儿治疗组身高呈逐渐增高趋势,GV呈先升高再降低趋势,HtDSD呈逐渐升高趋势,对照组身高、GV、HtDSD变化趋势不明显,治疗组身高、GV和HtDSD均明显高于对照组,其组间、时点间、组间时点间交互作用差异有统计学意义(P<0.05)。2组GHD及ISS患儿治疗前和治疗6个月以及治疗前后骨龄差异均无统计学意义(P>0.05)。结论矮小症患儿病因多种,以ISS及GHD患儿多见;GHD及ISS患儿早期应用重组人生长激素治疗可实现追赶性生长。Objective To explore the etiology of dwarfism and observe the effect of recombinant human growth hormone on growth hormone deficiency（GHD）and idiopathic short stature（ISS）.Methods The 485 cases of dwarfism were classified according to the etiology.The pre-pubertal GHD and ISS children were divided into the recombinant human growth hormone treatment group and the control group,and height,growth rate（GV）and height standard deviation score（HtSDS）were compared before and 3 months after treatment and 6 months after treatment.Bone age was compared before treatment and 6 months after treatment.ResultsAmong the children with dwarfism,ISS had a maximum of 185 cases,followed by GHD 140 cases,and rare disease was found.In the GHD and ISS groups,the height of the treatment group increased gradually,the GV increased first and then decreased,and the HtDSD increased gradually.The changes of height,GV and HtDSD in the control group were not obvious.Height,GV and HtDSD in the treatment group were significantly higher than those in the control group.There was statistically significant difference in interaction between groups,between time points and between groups（P〈0.05）.Conclusion The causes of dwarfism in children were various,and ISS and GHD were more common.The application of recombinant human growth hormone in the early stage of patients with GHD and ISS can achieve catch-up growth.

关 键 词：生长障碍 生长激素 儿童 

分 类 号：R59[医药卫生—内科学]