447例疑似ABO新生儿溶血病血清学试验结果  

Analysis on Serological Test Results in 477 Cases of Suspected Neonatal ABO Hemolytic Disease

作　　者：谭建玲 李江[1] 许广芳[1] 徐应芳[1] TAN Jian-ling;LI Jiang;XU Guang-fang;XU Ying-fang(Dept.of Transfusion,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院输血科,云南昆明650101

出　　处：《昆明医科大学学报》2018年第9期73-76,共4页Journal of Kunming Medical University

基　　金：昆明市卫计委科研基金资助项目(2017-11-01-014)

摘　　要：目的分析447例疑似ABO新生儿溶血病(ABO-HDN)血清学试验结果,为临床诊断和治疗HDN提供实验室依据.方法选取2015年7月至2017年8月在昆明医科大学第二附属医院送检的怀疑为ABO-HDN的447例标本进行血型鉴定和新生儿溶血3项试验检测,探讨HDN阳性率与血型、性别、送检日龄的关系.结果447例送检标本中310例证实为ABO-HDN,阳性率为69.4%.447例疑似标本中溶血3项试验A型的阳性检出率显著高于B型(P<0.05);不同性别的患儿溶血3项试验阳性检出率基本一致,差异无统计学意义(P>0.05);患儿出生0~3 d和4~7 d送检标本溶血3项试验阳性检出率均高于>7 d的患儿,差异有统计学意义(P<0.05).结论血清学检测有助于ABO-HDN的早期诊断和治疗,新生儿血型和标本送检时间对试验结果有明显的影响,新生儿性别对结果无影响.Objective To analyze the serological test results in 447 cases of suspected neonatal ABO hemolytic disease（ABO-HDN）and to provide the laboratory evidence for clinical diagnosis and treatment of HDN.Methods The blood samples of 477 cases that had been suspected to ABO-HDN from July 2015 to August 2017 in the 2 nd Affiliated Hospital of Kunming Medical University were selected for blood type and three hemolysis test with a purpose to investigate the relationship between positive rate of HDN with the related factors such as blood type, gender, the specimens collecting time. Results There were 310 cases of ABO-HDN in the total447 blood samples with the incidence 69.4%. Detection three hemolysis test positive rate of type A was significantly higher than that of type B（P 〈 0.05）. The three hemolytic test positive rate of gender was basically consistent and the statistics showed that the difference was not significant（P 〉 0.05）. The positive rates of three hemolysis test of newborns among 0-3 d and 4-7 d were higher than 〉7 d, and the difference of birth was statistically significant（P 〈 0.05）. Conclusion Serum test contributes to the early diagnosis and treatmenr of ABO-HDN, and the blood type of newborns and sample submission time have the obvious effect on the experimental results and there is no effect on the gender of newborns.

关 键 词：新生儿溶血病 直抗试验 游离抗体试验 抗体放散试验 

分 类 号：R722.18[医药卫生—儿科]