白介素-35在炎症及自身免疫性疾病中的免疫学效应及临床意义  

Immunological effects and clinical significance of interleukin-35 in inflammatory and autoimmune diseases

作　　者：吴田田[1,2] 童亚林 姚咏明[1] Wu Tiantian;Tong Yalin;Yao Yongming(Trauma Research Center,First Hospital Affliated to the Chinese PLA General Hospital,Beijing 100048,China;Hepatobiliary Surgery Department of Peking University International Hospital,Beijing 102206,China;Department of Burn and Plastic Surgery,181st Hospital of Chinese PLA,Guilin 541002,China)

机构地区：[1]解放军总医院第一附属医院创伤研究中心,北京100048 [2]北京大学国际医院肝胆外科,北京102206 [3]解放军第一八一医院烧伤整形中心,桂林541002

出　　处：《中华重症医学电子杂志》2018年第4期314-319,共6页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：国家自然科学基金重点项目(81730057;81372054;81772120);国家重点研发计划项目(2017YFC1103302);漓江学者计划资助项目

摘　　要：白介素(IL)-35是新近发现的IL-12家族抑制性细胞因子,在T细胞、B细胞免疫应答及传播性免疫耐受过程中发挥重要调控作用。目前尚未发现IL-35具备促炎效应。新近,炎症及自身免疫性疾病的相关基础及临床研究揭示了IL-35的病理生理学意义及其对疾病发生、发展及转归的重大影响。IL-35有望成为炎症及自身免疫性疾病诊断、监测及判断预后的重要免疫学指标,也是潜在的调控、治疗靶点。对IL-35表达及调控的深入研究,将为临床诊治炎症及自身免疫性疾病提供崭新的思路及方向。Interleukin-35 （IL-35） is a newly identi？ed inhibitory cytokine of IL-12 family. In a variety of immune responses mediated by T and B cells, IL-35 has been proved to play a vital role of immunological regulation. IL-35 further contributes to the propagation of immune tolerance, which is crucial for maintenance of immune balance and restriction of inflammatory injuries. Heretofore, no pro-inflammatory effects of IL-35 have been discovered. Recent basic and clinical studies on inflammatory and autoimmune diseases have revealed the pathophysiological significance of IL-35 and its significant impact on the occurrence, development and prognosis of diseases. IL-35 is expected to become an important immunological marker for the diagnosis, monitoring and prognosis of in？ammatory and autoimmune diseases, as well as a potential target for regulation and treatment. The in-depth study of IL-35 expression and regulation will provide new ideas and directions for clinical diagnosis and treatment of in？ammatory and autoimmune diseases.

关 键 词：白介素-35 炎症性疾病 自身免疫性疾病 免疫学效应 诊断 监测 

分 类 号：R593.2[医药卫生—内科学]