泼尼松联合转移因子治疗免疫性不孕症的疗效及对细胞免疫功能的影响  

Effect of Prednisone Combined Transfer Factor in the Treatment of Immune Infertility Curative Effect and Cellular Immune Function

作　　者：王文娟[1] Wang Wenjuan(Reproductive Center of The People＇s Hospital of Qinghai（810007)

机构地区：[1]青海省人民医院生殖中心,810007

出　　处：《青海医药杂志》2018年第6期4-7,共4页Qinghai Medical Journal

摘　　要：目的:观察泼尼松联合转移因子治疗免疫性不孕症的疗效及对细胞免疫功能的影响。方法:将136例女性免疫性不孕症患者随机分为对照组和联合治疗组各68例,对照组患者仅采用醋酸泼尼松+维生素E+维生素C治疗;联合治疗组首先采用醋酸泼尼松+维生素E+维生素C治疗,10d后再加用转移因子治疗;以30d为一个疗程,观察两组妊娠情况、抗精子抗体(antisperm antibody,AsAb)水平、滤泡性辅助性T细胞(Follicular helper T cells,Tfh)占CD4+细胞的比例(Tfh/CD4+)以及患者不良反应发生情况。结果:联合治疗组AsAb水平以及Tfh/CD4+明显低于对照组,差异具有统计学意义(P<0.05);联合治疗组总有效率为89.7%,显著高于对照组总有效率70.6%(P<0.05);联合治疗组不良反应率为8.8%,对照组不良反应率为10.3%(P>0.05)。结论:泼尼松联合转移因子治疗免疫性不孕症,可有效降低AsAb水平及Tfh/CD4+,能良好地调节细胞免疫功能,临床疗效明显,且不会增加不良反应,值得临床推广应用。Objective：This study is aimed to observe the curative effect of prednisone combined with transfer factor on immune infertility and cellular immune function.Methods：136 cases of immune infertility were randomly divided into control group and treatment group with 68 cases for each group.The control group was only given prednisone with vitamin E and vitamin C for treatment while the treatment group was given prednisone with vitamin E and vitamin C adding transfer factor treatment after 10 days with 30 days as a course of treatment.Both groups were observed for their pregnancy situations,anti sperm antibody（AsAb）levels,Tfh accounted for CD4＋ cell ratio（Tfh/CD4＋）and adverse reactions.Results：The level of AsAb and Tfh/CD4＋ in treatment group was significantly lower than control group,whose difference was statistically significant（P〈0.05）.The total effective rate of the treatment group was 89.7%,which was significantly higher than control group whose total effective rate was 70.6%,and the difference between two groups was statistically significant（P〈0.05）.The adverse reaction rate of the treatment group was 8.8%,which was 10.3% in the control group without statistically significant difference（P〈0.05）.Conclusion：Prednisone plus transfer factor in the treatment of immune infertility can effectively reduce the level of AsAb and Tfh/CD4＋,adjust the cellular immune function,and have a good curative effect.It also can＇t increase the adverse reactions to be worth spreading in clinical application.

关 键 词：泼尼松 转移因子 免疫性不孕症 免疫功能 

分 类 号：R271.14[医药卫生—中医妇科学] R446.63[医药卫生—中医学]