植物天然产物合成生物学研究  

Synthetic Biology for Production of Plant-derived Natural Products

作　　者：戴住波[1] 王勇[2] 周志华[2] 李盛英[3] 张学礼[1] DAI Zhubo;WANG Yong;ZHOU Zhihua;LI Shengying;ZHANG Xueli(Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China;Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China)

机构地区：[1]中国科学院天津工业生物技术研究所 [2]中国科学院上海生命科学研究院植物生理生态研究所 [3]中国科学院青岛生物能源与过程研究所

出　　处：《中国科学院院刊》2018年第11期1228-1238,共11页Bulletin of Chinese Academy of Sciences

基　　金：中国科学院青年创新促进会项目(2015138)

摘　　要：植物天然产物在医药健康领域有着广泛的应用。从植物中直接提取是目前生产植物源天然产物的主要方法,但此法在环境、安全和效率等方面存在诸多问题。基于合成生物学的理念,创建人工细胞工厂发酵生产植物源天然产物是一种新的资源获取模式。文章将从研究路线出发,在萜类、苯丙素类和生物碱等化合物的生产应用案例中,介绍人工合成细胞生产植物源天然产物的研究现状。Plant-derived natural products（PNPs） have been widely used in pharmaceutical and neutracuetical fields. Currently, extracting PNPs from their original plants is the main method to produce them. However, this extracting method is environmentally unfriendly, unsafe, and inefficient. Based on synthetic biology, construction of artificial cell factories for production of PNPs provides an alternative way. In this review, we focus on research progress for microbial production of terpenoids, alkaloids, and phenylpropanoids to give a brief introduction of construction of artificial cell factories for production of PNPs.

关 键 词：植物天然产物 合成生物学 微生物细胞工厂 萜类 

分 类 号：Q81[生物学—生物工程]