缓释制剂不同制备技术的研究及其应用进展  

Research and application progress of different preparation techniques for sustained release preparation

作　　者：朱颖[1] 乔颖玉 杨钰娜 李凯龙 葛亮[1] ZHU Ying;QIAO Ying-yu;YANG Yu-na;LI Kai-long;GE Liang(Department of Pharmacy,China Medicine University,Jiangsu Nanjing 210009,China)

机构地区：[1]中国药科大学药剂学教研室,江苏南京210009

出　　处：《中国医院药学杂志》2018年第20期2179-2184,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然基金项目(编号:81760638);国家自然基金项目(编号:81572978)

摘　　要：缓释制剂是目前被医药领域广泛研究和应用的一种新型制剂。与普通制剂相比,缓释制剂具有提高病人顺应性,降低药物毒副作用以及减少用药总剂量等优点,使得药物发挥最佳的治疗效果。根据制备技术的不同,缓释制剂可分为骨架型、膜控型、渗透泵型以及双重缓释型制剂。本文阅读参考相关文献,整理与总结了由不同工艺所制备的缓释制剂的研究进展。Sustained release preparation（SRP）is a novel kind of preparation which is extensively studied and applied in the field of pharmaceutical sciences.Compared with conventional preparations,SRP has the advantages of improving patient compliance,reducing drug toxicity and the total dose of drugs,and producing the best treatment results.According to the different preparation techniques,SRP can be divided into the matrix type,film-coated type,osmotic pump type and double sustained release type.The research progress and application of SRP prepared by different techniques are summarized in this paper.

关 键 词：缓释制剂 骨架制剂 膜控释 双重缓释 

分 类 号：R943[医药卫生—药剂学]