抗菌肽对口腔致龋菌抗菌作用的研究进展  

Research progress on activity of antimicrobial peptides to oral cariogenic bacteria

作　　者：涂欢芯 章可可 任佩琪 胡翔宇 孙妍 潘乙怀[1] Tu Huan-xin;Zhang Ke-ke;Ren Pei-qi;Hu Xiang-yu;Sun Yan;Pan Yi-huai(Department of Endodontics,Hospital of Stomatology,Wenzhou Medical University,Wenzhou 325000;Institution of Stem Cell and Tissue Engineering,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou 325000)

机构地区：[1]温州医科大学附属口腔医院牙体牙髓科,温州325000 [2]温州医科大学口腔医学院干细胞与组织工程研究所,温州325000

出　　处：《中国抗生素杂志》2018年第11期1349-1354,共6页Chinese Journal of Antibiotics

基　　金：温州市科技计划项目(No.Y20150077和No.Y20170190)

摘　　要：抗菌肽是生物体免疫系统产生的一类抵抗外界病原体感染的多肽类及其衍生物。抗菌肽种类繁多,来源广泛,且具有高效广谱的抗菌活性,对多种口腔常见致龋菌有较好的抗菌作用。本文就不同来源的抗菌肽对口腔致龋菌作用效果的研究进展作一综述,为抗菌肽在龋病的药物防治方面提供参考。Antimicrobial peptides are a kind ofpeptides and their derivatives which are produced by the immune system of organisms to resist the infection of external pathogens. Antimicrobial peptides are ubiquitous occuring with various sources, and exert a broad-spectrum antibacterial activity to many cariogenic bacteria. This review focuses on the effect of antimicrobial peptides from different sources on oral cariogenic bacteria, aiming to provide a reference for the studies of controlling caries with antimicrobial peptides.

关 键 词：抗菌肽 口腔致龋菌 变异链球菌 龋齿 

分 类 号：R978[医药卫生—药品] R78[医药卫生—药学]