Meso-四(对甲基苯基)卟啉及其钴配合物的光学性能与生物应用  

Optical Properties and Biological Applications of Meso-tetrakis(p-methylphenyl)Porphyrin and Its Cobalt Complex

作　　者：张万宇[1] 张晓娟[1] 佟佳霖 陈天赐 田俊强 胡蓉 王志明 ZHANG Wan-Yu;ZHANG Xiao-Juan;TONG Jia-Lin;CHEN Tian-Ci;TIAN Jun-Qiang;HU Rong;WANG Zhi-Ming(School of Petrochemical Engineering,Shenyang University of Technology,Liaoyang,Liaoning 111003,China;Shenzhen Research Institute,The Hong Kong University of Science and Technology,Shenzhen,Guangdong 518000,China)

机构地区：[1]沈阳工业大学石油化工学院,辽阳111003 [2]香港科技大学深圳研究院,深圳518000

出　　处：《无机化学学报》2018年第12期2161-2171,共11页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.51673118);深圳市基础研究计划项目(No.JCYJ20160428150429072)资助

摘　　要：对meso-四(对甲基苯基)卟啉(TMPP)和meso-四(对甲基苯基)卟啉钴(TMPP-Co)的溶剂化效应及其水相体系下的发光机理进行了细致地研究。发现TMPP在与钴离子配位后发光强度明显下降;TMPP-Co的溶剂化效应不仅与溶剂极性有关,还与Co离子的轴向配位有关;TMPP与TMPP-Co在水相条件下及在甘油中的发光强度呈现先上升后下降的趋势。此外,TMPP-Co产生单线态氧的能力较强;通过制备TMPP-TAT-NPs纳米粒子成功实现对细胞的染色,并局域在细胞溶酶体上。The solvation effects of meso-tetrakis（p-methylphenyl） porphyrin （TMPP） and meso-tetrakis（p-methylphenyl） porphyrin cobalt （TMPP-Co）, and the luminescence mechanism in aqueous systems have been studied in detail. It was found that the luminescence intensity of TMPP after the complexation of cobalt ions decreased significantly; the solvation effect of TMPP-Co was not only related to the polarity of the solvent but also related to the axial coordination of Co ions. The luminous intensities of TMPP and TMPP-Co showed a trend of increase and then decrease both in aqueous phase and in glycerol. In addition, TMPP-Co has a strong ability to generate singlet oxygen; the preparation of TMPP-TAT-NPs nanoparticles successfully stained cells and localized to the cell lysosomes.

关 键 词：TMPP 溶剂化效应 单线态氧 细胞染色 

分 类 号：O614.812[理学—无机化学] O614.4[理学—化学]