肿块型乳腺浸润性导管癌MR环状强化的组织病理学及影像特点分析  

Correlation between rim enhancement and common histopathological prognostic factors and the features of MR imaging in mass type invasive ductal breast cancer

作　　者：赵倩 李莹 陈宗耀 刘莉 刘光 王帅 ZHAO Qian;LI Ying;CHEN Zongyao;LIU Li;LIU Guang;WANG Shuai(Department of Radiology,PLA Army General Hospital,Beijing 100700,China;Department of Pathology,PLA Army General Hospital,Beijing 100700,China;Institute of Hepatology,PLA Army General Hospital,Beijing 100700,China)

机构地区：[1]陆军总医院放射诊断科,北京100700 [2]陆军总医院病理科,北京100700 [3]陆军总医院全军肝病中心,北京100700

出　　处：《中国体视学与图像分析》2018年第3期229-234,共6页Chinese Journal of Stereology and Image Analysis

摘　　要：目的探讨肿块型乳腺浸润性导管癌环状强化与组织病理学及MR特征的相关性。方法回顾性分析经病理学证实的乳腺浸润性导管癌并行术前乳腺MR动态增强扫描患者。进行病理组织学分级及ER、PR、HER-2及Ki67免疫组化染色。由两名放射科医生独立阅片确定病变MRI影像特点。病变形态为肿块型病例纳入研究,根据强化方式分为环状强化组及非环状强化组。评价指标包括:病变的长径、形态、边界,边缘、时间信号强度曲线(time signal intensity curve,TIC)类型。结果 130例患者符合入组条件。环状强化组,ER及PR阴性、HER-2阳性的概率比非环状强化组高,环状强化也与肿瘤分叶、边界不清相关(P<0. 05)。肿瘤病理组织分级、Ki67表达、肿瘤的大小、形状、TIC与环状强化不显著相关。结论肿块型乳腺浸润性导管癌MR环状强化可能与预后存在一定关联。Objective To evaluate the correlation between rim enhancement on magnetic resonance （MR） and common histopathological prognostic factors and the features of MR imaging in mass type invasive ductal breast cancer. Methods Consecutive cases of pathologic proven invasive ductal breast carcinoma were reviewed. These cases owned the results of molecular markers, including Ki67, ER, PR, and HER-2 and were performed dynamic MR imaging before surgery or biopsy. Those cases which showed mass-like enhancement were included. Two radiologists independently evaluated the MR images. Based on the type of enhancement, all the subjects were divided into two groups, the rim enhancement group and the non-rim-like group. The size, shape, boundary, margin and the time signal intensity curve （TIC） type of the lesions were evaluated. Results 130 patients were enrolled in our study. The negative ratios of ER, PR and positive ratios of HER-2 were higher in the invasive cancers with rim enhancement than those without rim enhancement （ P 〈 0.05 ） ~ There was significant correlation between rim enhancement and unclear boundary, lobulated margin. There were no significant differences in histological grade, Ki67, and other features on MR imaging between the two groups. Conclusions Rim enhancement patterns of mass type invasive ductal breast cancer on contrast-enhanced MR imaging is related to common histopathological prognostic factors. The pattern may be useful in evaluating prognosis.

关 键 词：乳腺 癌症 磁共振成像 环状强化 

分 类 号：R445.2[医药卫生—影像医学与核医学]