糖化血红蛋白检测技术的发展  

Development of measurement technology for glycated hemoglobin

作　　者：纪玲[1] Ji Ling(Department of Laboratary Medicine,Peking University Shenzhen Hospital,Shenzhen 518036,China)

机构地区：[1]北京大学深圳医院检验科,深圳518036

出　　处：《中华检验医学杂志》2018年第11期808-811,共4页Chinese Journal of Laboratory Medicine

摘　　要：糖化血红蛋白（HbA1c）是血液中的葡萄糖与血红蛋白β链N末端缬氨酸残基以共价键结合的稳定的化合物。HbA1c是血糖长期水平监测的金标准，其水平与并发症有密切关系。美国糖尿病协会于2010年推荐HbA1c为糖尿病诊断标准。HbA1c检测技术日新月异，已经有基于多种不同原理的方法应用于HbA1c检测。本文概括常用的HbA1c检测方法包括高效液相色谱法、免疫法、酶法和电泳法等，并介绍HbA1c检测方法的发展和展望。Hemoglobin A1c（HbA1c） is a glycated hemoglobin characterized by non-enzymatic binding of glucose to the N-terminal valine residue on the β-chain of the hemoglobin A, is widely utilized as a golden biomarker for diabetes mellitus management because it provides valuable information for long-term glycemic control and assessment of patient risk for chronic complications. In 2010 the American Diabetes Association （ADA） suggested a cut-off value of 6.5% （48 mmol/mol） HbA1c to diagnose diabetes. The rapid development of measurement technology has led to the application of kits based on different principles to detect HbA1c. This review summarizes the common HbA1c methods including high performance liquid chromatography, immunoassay, enzymatic, and electrophoresis, and briefly introduces the development of measurement technology for HbA1c.

关 键 词：血红蛋白A  糖基化 临床实验室技术 临床化学试验 

分 类 号：R587.1[医药卫生—内分泌]