舒芬太尼预注射对丙泊酚注射痛的影响  

Effects of sufentanil pre-injection on propofol injection pain

作　　者：黄仰发[1] 黄其健[1] 曾建 许小平 李玉梅[1] 曾邦伟[1] 翁险峰[1] Huang Yangfa;Huang Qijian;Zeng Jian;Xu Xiaoping;Li Yumei;Zeng Bangwei;Weng Xianfeng(Department of Anesthesiology,Fujian Medical University Union Hospital,Fuzhou,Fujian,350001,China)

机构地区：[1]福建医科大学附属协和医院麻醉科,福建福州350001

出　　处：《当代医学》2018年第34期101-104,共4页Contemporary Medicine

基　　金：福建省卫计委青年科研课题(2015-1-36)

摘　　要：目的探讨舒芬太尼预注射对丙泊酚注射痛的影响。方法 60例ASAⅠ～Ⅱ级的择期行单侧大隐静脉高位结扎加点式剥脱术患者,随机分成研究组和对照组,每组30例,麻醉诱导期间的所有药物输注都使用微注泵完成,所有的药物都制成50 ml溶液。研究组的麻醉诱导药物注射顺序为舒芬太尼(浓度:2μg/ml,剂量:0.4μg/kg,注射时间:2 min;下同)、丙泊酚(10 mg/ml,2 mg/kg,30 s)、生理盐水(9 mg/ml,注射容量与舒芬太尼相同,2 min)维库溴铵(1 mg/ml,0.1 mg/kg,30 s);对照组为生理盐水、丙泊酚、舒芬太尼、维库溴铵;观察记录丙泊酚注射痛的程度以及舒芬太尼预注射产生的反应。结果舒芬太尼预注射可以明显减轻丙泊酚的注射痛;研究组中24例(80%)出现注射痛,对照组为29例(96.67%),研究组中无痛与轻度痛的比例大于对照组,重度痛在研究组为1例(3.33%),对照组为10例(33.33%),研究组和对照组的注射痛程度差异具有统计学意义(Z=-3.944,P<0.001)。研究组中13例(43.33%)出现头晕、视物旋转,对照组为1例(3.33%);研究组中8例(26.67%)出现恶心不适,两组的头晕、视物旋转、恶心等不良反应差异对比有统计学意义(c2=28.812,P<0.001)。结论舒芬太尼预注射可以作为减轻丙泊酚注射痛的方法之一,但同时也应注意所产生的不良反应。Objective To investigate the effects of sufentanil pre-injection on pain following propofol injection. Methods Sixty patients in American Society of Anesthesiologists class I or II, who underwent elective unilateral high ligation and stripping of the great saphenous vein, were randomly assigned to a test or control group （n = 30 each）. All drug administration during anesthesia induction was performed using a pump and all drugs were made into 50 ml solutions.The sequence of intravenous drugs for anesthesia induction in the test group was sufentanil （ concentration： 2 μg/ml, dosage： 0.4 μg/kg, injection rate：in 2 min ; similarly hereinafter ）, propofol （ 10 mg/ml, 2 mg/kg, in 30 s ）, normal saline（ 9 mg/ml, injection volume equal sufentanil, in 2 min ） ,and vecuronium bromide（ 1mg/ml, 0.1 mg/kg, in 30 s ）; while the control group was normal saline, propofol, sufentanil, and vecuronium bromide. During propofol administration, the patients were asked about their pain status. Assessment included standard questions regarding comfort of the injection, verbal response, and behavioral signs. Results Sufentanil pre-injection significantly decreased pain on injection of propofol. Twenty-nine patients （96.67%） complained of pain in the control group pretreated with normal saline as compared with 24 （80%）in the test group pretreated with sufentanil. The incidence of no pain and mild pain was more in the test group when compared with control group. Severe pain was more in the control group（10, 33.33%） when compared to test group（1, 3.33%）. The difference of pain severity between the two groups was statistically significant （Z =-3.944;P〈0.001）. Thirteen patients （43.33%） complained of dizziness/vertigo in the test group pretreated with sufentanil as compared with 1 （3.33%）in the control group pretreated with normal saline. Eight patients （26.67%） complained of nausea in the test group. Differences of adverse reaction between the two groups were statistically signi

关 键 词：舒芬太尼 丙泊酚 注射痛 

分 类 号：R614[医药卫生—麻醉学]