类风湿关节炎与肺部阻塞性疾病相关性的Meta分析  

A meta analysis of the correlation between rheumatoid arthritis and obstructive lung disease

作　　者：邹荣鑫 李晓可 褚赞波[1,2] 应颖 彭勇[1] 陈勇[1] Zou Rongxin;Li Xiaoke;Chu Zanpo;Ying Ying;Peng Yong;Chen Yong(Department of Rheumatology,Ningbo No.2 Hospital,Ningbo 315010,China;School of Medicine,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波市第二医院风湿免疫科,浙江宁波315010 [2]宁波大学医学院,浙江宁波315211

出　　处：《临床荟萃》2018年第11期983-986,共4页Clinical Focus

基　　金：宁波市自然基金项目(2015A610206;2017A610208)

摘　　要：目的系统评价类风湿关节炎(rheumatoid arthritis,RA)与肺部阻塞性疾病的相关性。方法计算机检索Pubmed、embase数据库,对RA并发慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)和哮喘的临床随机对照研究进行检索,采用Revman 5.3软件进行数据分析。结果最终纳入文献7篇,包括RA患者91 191例,对照组246 923例。采用随机效应模型,RA组发生肺部阻塞性疾病的危险性大于对照组(OR=1.81,95%CI=1.64～2.01,P <0.01)。结论 RA与肺部阻塞性疾病发病密切相关,RA患者COPD和哮喘的发生风险显著增加。Objective To evaluate the association between rheumatoid arthritis（RA） and obstructive lung disease（OLD）.Methods The databases of Pubmed, Embase were searched for randomized controlled clinical trials related to the association between RA and OLD. Revman 5.3 software was used for meta-analysis.Results A total of 7 studies including 91 191 rheumatoid arthritis patients and 246 923 non-RA control subjects were eligible for the meta-analysis. According to random-effect meta-analysis model, the risk of OLD was higher in RA patients compared to non-RA controls（ OR = 1.81 ,95% CI = 1.64 - 2.01 , P 〈 0.01 ）.Conclusion RA is closely related to the incidence of pulmonary obstructive diseases and patients with RA face higher risk of COPD and asthma.

关 键 词：关节炎 类风湿 肺疾病 慢性阻塞性 哮喘 META分析 

分 类 号：R593.22[医药卫生—内科学]