小剂量铁剂在小儿缺铁性贫血治疗中的效果分析  

Effect analysis of low-dose chalybeate in treatment of infantile iron deficiency anemia

作　　者：罗碧云 冼丹霞 LUO Biyun;XIAN Danxia(Department of Prevention and Healthcare,Longhua District Maternal and Child Health Hospital,Guangdong Province,Shenzhen 518109,China)

机构地区：[1]深圳市龙华区妇幼保健院预防保健科,广东深圳518109

出　　处：《中国医药科学》2018年第20期36-39,共4页China Medicine And Pharmacy

摘　　要：目的探讨小剂量铁剂在小儿缺铁性贫血治疗中的临床效果。方法研究时间为2017年1月～2018年1月,研究对象选择200例就诊于我院的小儿缺铁性贫血患儿,应用随机数字表法将这200例缺铁性贫血患儿随机分为两组,每组100例,两组均采取饮食调节干预,在饮食调节干预的基础上,对照组采用常规剂量铁剂治疗,观察组采用小剂量铁剂治疗,比较两组的临床疗效、营养状况指标、免疫功能指标、不良反应。结果在临床疗效方面,观察组的总有效率为94%,对照组的总有效率为97%,组间比较无统计学意义(P> 0.05)。在营养状况方面,治疗后,两组患儿的血红蛋白、白蛋白、转铁蛋白等营养状况指标均较治疗前显著增高(P <0.05),而组间血红蛋白、白蛋白、转铁蛋白比较,差异均无统计学意义(P> 0.05)。在免疫功能方面,治疗后,两组患儿的CD3^+、CD4/CD8等免疫功能指标均较治疗前显著增高(P <0.05),而组间各项免疫功能指标比较,差异均无统计学意义(P> 0.05)。在不良反应方面,观察组的总发生率低于对照组(P <0.05)。结论在小儿缺铁性贫血治疗时,给予患儿小剂量铁剂治疗可达到与常规铁剂治疗相当的临床疗效,可对患者营养状况、免疫功能予以有效改善,还能减少患儿用药后的不良反应。Objective To study and explore the clinical effect of low-dose ehalybeate in treatment of Infantile iron deficiency anemia. Methods 200 children with iron deficiency anemia who were treated in our hospital from January 2017 to January 2018 were selected as research objects. They were randomly divided into two groups according to random nmnber table, with 100 in each group. Two groups were both given diet regulation intervention. On the basis of it, the control group was treated with conventional dose ehalybeate while the observation group was treated with low-dose ehalybeate. Clinical curative effect, nutritional status index and immune function index and adverse reactions of two groups were compared. Results In clinical curative effect, the total effective rate of observation group was 94% and that of control group was 97%. There was no significant difference between two groups （P 〉 0.05）.In terms of nutritional status, levels of hemoglobin, albumin and transferrin after treatment of two groups were significantly higher than before （P 〈 0.05）, but there was no significant difference in hemoglobin, albumin and transferrin between two groups （P 〉 0.05）.In immune function, immunological function indexes after treatment such as CD3＋. CD4/CD8 were all significantly higher than those before treatment （ P 〈 0.05）, but there was no significant difference between two groups （P 〉 0.05）. The total incidence of adverse reactions in the observation group was lower than that in the control group （P 〈 0.05）. Conclusion Low-dose ehalybeate in treatment of infantile iron deficiency anemia can achieve the same clinical effect as the conventional chalybeate treatment. It can effectively improve the nutritional status and immune function of children and also reduce the adverse reactions after medication.

关 键 词：缺铁性贫血 营养状况 小剂量铁剂 免疫功能 

分 类 号：R725.5[医药卫生—儿科]