中草药对细菌耐药质粒的消除作用研究  

Study on Elimination of Bacterial Drug Resistant Plasmids by Chinese Herbs

作　　者：朱利霞 王洪彬 史秋梅[1] 高光平[1] ZHU Li-xia;WANG Hong-bin;SHI Qiu-mei;GAO Guang-ping(Hebei Normal University of Science ＆Technology,Hebei Key Laboratory of Preventive Veterinary Medicine,Qinhuangdao,066004,China)

机构地区：[1]河北科技师范学院河北省预防兽医学重点实验室,秦皇岛066604

出　　处：《中国兽药杂志》2018年第11期72-79,共8页Chinese Journal of Veterinary Drug

基　　金：河北省自然科学基金项目(C2015407033);河北省自然科学基金项目(C2015407033);河北省教育厅(SLRC2017037);河北省高层次人才资助项目(A2016005046);河北科技师范学院科学研究基金项目(无编号)

摘　　要：动物养殖中常见病原菌对抗菌药物的耐药性呈逐年上升的趋势,引起了广大科研工作者的极大关注。病原菌耐药性的产生主要与质粒有关,质粒能够将耐药基因传递给环境中的其他细菌,进而引起多重耐药菌株的出现。本文就细菌耐药现状、细菌耐药性与质粒关系、中草药对细菌耐药质粒的消除效果、中草药消除耐药质粒的机理、存在的问题、中草药对耐药质粒消除的展望进行综述。The resistance of common pathogenic bacteria to antibacterial drugs in animal breeding has beenincreasing year by year, which has aroused the great concern of researchers. The generation of drug resistance ofpathogens is mainly related to plasmids. Plasmids can transmit drug resistance genes to other bacteria in theenvironment, causing the emergence of multiple drug-resistant strains. This article briefly reviews the currentstatus of bacterial drug resistance, the elimination effects of Chinese herbal medicines on bacterial drug resistanceplasmids, the mechanism of elimination of resistant plasmids by Chinese herbal medicines, existing problems, andthe prospects for elimination of drug resistant plasmids by Chinese herbs.

关 键 词：中草药 耐药性 质粒消除 

分 类 号：S859.3[农业科学—临床兽医学]