类风湿关节炎病人外周血中趋化因子受体CXCR4与其配体SDF-1α的表达研究  

Study on the expression of chemokine receptor CXCR4 and its ligand SDF-1α in peripheral blood of patients with rheumatoid arthritis

作　　者：任春凤[1] 段国庆[2] REN Chun-feng;DUAN Guo-qing(Department of Rheumatology and Immunology,The First People＇s Hospital of Jining,Jining Shandong 272000;Department of Bone and Joint,The Affiliated Hospital of Jining Medical College,Jining Shandong 272000,China)

机构地区：[1]山东省济宁市第一人民医院风湿免疫科,272000 [2]济宁医学院附属医院骨关节科,山东济宁272000

出　　处：《蚌埠医学院学报》2018年第11期1437-1439,共3页Journal of Bengbu Medical College

基　　金：山东省济宁市医疗卫生科技计划项目(2015-57-48)

摘　　要：目的：探讨类风湿关节炎病人外周血中趋化因子受体CXCR4与其配体SDF-1α的表达水平。方法：选取类风湿性关节炎病人52例为观察组。另外选取同期健康体检的健康人群30名为对照组。采集受试者静脉血,检测外周血CXCR4、SDF-1α及白细胞介素（IL）-8表达水平。结果：观察组外周血CD3^＋CD4^＋和CD3^＋CD8^＋T淋巴细胞表面CXCR4表达百分率和血清SDF-1α、IL-8表达水平均高于对照组（P 〈0. 01）。随着病程的延长,外周血CD3^＋CD4^＋和CD3^＋CD8^＋T淋巴细胞表面CXCR4表达百分率和血清SDF-1α表达水平上升（P 〈0. 01）。直线相关性分析结果显示,外周血CXCR4及SDF-1α表达水平与IL-8均呈正相关关系（P 〈0. 05）。结论：SDF-1α/CXCR4信号转导通路和IL-8与类风湿性关节炎的发病和进展过程有关。Objective： To investigate the expression levels of chemokine receptor CXCR4 and its ligand SDF-1α in peripheral blood of patients with rheumatoid arthritis. Methods： Fifty-two patients with rheumatoid arthritis and 30 healthy people were divided into the observation group and control group,respectively. The levels of CXCR4,SDF-1α and IL-8 in peripheral blood of two groups were measured. Results： The expression rates of CXCR4 on the surface of CD3^＋CD4^＋and CD3^＋CD8^＋T lymphocytes,and levels of SDF-1αand IL-8 in peripheral blood of observation group were significantly higher than those in control group（ P〈0. 05）. With the prolonging of disease course,the expression rates of CXCR4 on the surface of CD3^＋CD4^＋and CD3^＋CD8^＋T lymphocytes,and level of SDF-1α in peripheral blood of observation group increased（ P〈0. 05）. Linear correlation analysis showed that the expression levels of CXCR4 and SDF-1α were positive correlation with IL-8 in peripheral blood（ P〈0. 05）. Conclusions： The signal transduction pathway of SDF-1α/CXCR4 and IL-8 may be involved in the pathogenesis and progression of rheumatoid arthritis.

关 键 词：类风湿关节炎 趋化因子 CXCR4 SDF-1Α 白细胞介素-8 

分 类 号：R593.22[医药卫生—内科学]