中老年人尿靛甙水平检测与血清脂类及同型半胱氨酸水平的相关性分析  

Correlation between Uric Indicant Level and Serum Lipids and Homocysteine Levels in Middle-aged and Elderly Persons

作　　者：韩振 杨莉 HAN Zhen,YANG Li(Laizhou Rongjun Hospitat of Yantai, Shandong Laizhou 261400,China; Maternal and Child Health Care Hospital of Laizhou , Shandong Laizhou 261400, China)

机构地区：[1]烟台市莱州荣军医院,山东莱州261400 [2]莱州市妇幼保健院,山东莱州261400

出　　处：《现代检验医学杂志》2018年第6期77-79,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨中老年人尿靛甙水平检测与血清脂类及同型半胱氨酸(HCY)水平的相关性。方法选取莱州市50(含)岁以上健康查体者120例,随机分成实验组60例和对照组60例,实验组使用尿靛甙检测来建立个体化饮食营养指导,对照组使用普通健康教育指导,两组分别于实验前和实验结束时检测尿靛甙、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和同型半胱氨酸(HCY)水平并进行分析。结果实验组和对照组在实验开始前基本资料差异无统计学意义(P>0.05)。通过一年的回访和数据收集,实验结束时,实验组TC(5.47±0.85mmol/L vs 6.38±0.71mmol/L),TG(1.33±0.44 mmol/L vs 1.52±0.41 mmol/L),HDL-C(1.63±0.29 mmol/L vs1.83±0.40mmol/L),LDL-C(3.21±0.66mmol/L vs 3.85±0.72mmol/L),HCY(18.6±3.17μmol/L vs 21.7±3.08μmol/L)和尿靛甙(72.6±13.1mg/L vs 92.7±18.5mg/L)水平均低于对照组,差异有统计学意义(t=2.45～6.83,均P<0.05),实验组内比较,实验结束时TC(5.88±1.05mmol/L vs 5.47±0.85mmol/L),LDL-C(3.53±0.77mmol/L vs 3.21±0.66mmol/L),HCY(21.3±3.69μmol/L vs 18.6±3.17μmol/L)和尿靛甙(86.3±18.9mg/L vs 72.6±13.1mg/L)水平低于实验开始时,差异均有统计学意义(t=2.31～5.76,均P<0.05),而TG(1.38±0.73mmol/L vs 1.33±0.44mmol/L),HDL-C(1.75±0.37mmol/L vs 1.63±0.29mmol/L)在实验前后水平差异无统计学意义(t=1.22,1.09,P>0.05)。经Spearman相关性分析显示,尿靛甙水平与TC,LDL-C,HCY水平呈正相关关系(r分别为0.582～0.624,均P<0.05)。结论检测中老年人尿靛甙的水平可以有效降低血脂和同型半胱氨酸水平,从而降低中老年人患高血压、动脉粥样硬化等心血管疾病的风险。Objective To explore the correlation between urinary indigo glycoside and serum lipids and homocysteine levels in middle aged and elderly people. Methods 120 healthy subjects over 50 years old were randomly divided into experimental group （60 persons） and control group （60 persons） in Laizhou. Uric indicant monitoring was used to establish individualized dietary nutritional guidance for the experimental group, and the control group used general health education guidance. The levels of uric indicant, TG, HDL C, LDL C and HCY were analyzed before and after the experiment in both groups. Results There was no significant difference in the basic data between the experimental group and the control group before the start of the experiment （P〉0.05）. After one year＇s return visit and data collection,the level of TC （5.47±0.85 mmol/L vs 6.38± 0.71 mmol/L） ,TG（1.33±0.44 mmol/L vs 1.52±0.41 mmol/L） ,HDL- C（1.63±0.29 mmol/L vs 1.83±0.40 mmol/L）, LDL C（3.21±0.66 mmol/L vs 3.85±0.72 mmol/L） ,HCY（18.6±3.17 μmol/L vs 21.7±3.08 μmol/L） and uric indicant （72.6 ± 13.1 mg/L vs 92.7 ± 18.5 mg/L） in the experimental group were significantly different from the control group （t =2.45-6.83,all P〈0.05）. The levels of TC（5.88±1.05 mmol/L vs 5.47±0.85 mmol/L） ,LDL C（3.53±0.77 mmol/L vs 3.21±0.66 mmol/L）,HCY （21.3±3.69 μmol/L vs 18.6±3.17 μmol/L） and uric indicant （86.3±18.9 mg/L vs 72.6± 13.1 mg/L） in the experimental group were significantly different from those before the experiment （t= 2.31±5.76,all P 〈0.05） ,and there was no significant difference in the levels of TG （1.38±0.73 mmol/L vs 1.33±0.44 mmol/L） ,HDL C （1.75±0.37 mmol/Lvs 1.63±0.29 mmol/L） before and after the experiment （t =1. 22,1. 09, P〉0. 05）. Spearman corre lation analysis showed that uric indicant levels were positively correlated with TC, LDL C and HCY levels （ r =0. 582- 0. 624,all P〈0.05）. Conclusion Detection of uric indicant levels can effectively redu

关 键 词：尿靛甙 血脂 同型半胱氨酸 

分 类 号：R446.112[医药卫生—诊断学]