大白杜鹃中萜类化学成分研究  

Terpenoids Isolated from Rhododendron decorum

作　　者：陈新涛[1] 吕光辉 陈黎[1] CHEN Xin-tao;LYU Guang-hui;CHEN Li ＊(Department of Pharmacy,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]十堰市太和医院/湖北医药学院药学部,湖北十堰442000

出　　处：《中国现代中药》2018年第11期1347-1350,共4页Modern Chinese Medicine

基　　金：2017度太和医院软科学项目计划(2017rkt12)

摘　　要：目的:研究大白杜鹃Rhododendron decorum.枝叶的次级代谢产物。方法:利用硅胶、MCI、ODS、Sephadex LH-20、半制备HPLC等分离手段,对大白杜鹃的乙醇提取物进行分离纯化,对其理化性质、波谱数据进行分析并鉴定结构。结果:从大白杜鹃的95%乙醇提取物中分离鉴定了8个化合物,其中包括6个二萜类化合物,2个降倍半萜类化合物,分别是grayanotoxin I(1),grayanotoxin X(2),grayanotoxin VIII(3),rhododecorumin VII(4),leucothol A(5),grayanotoxin XXI (6),(+)-Dehydrovomifoliol (7),5α,6α-Epoxy-3β-hydroxy-megastigm-7-en-9-one(8)。结论:除了化合物4,其余化合物均为首次从大白杜鹃枝叶中分离得到。Objective： To investigate the secondary- metabolites of Rhododendron decorum. Methods： Silica gel, Sephadex LH-20, MPLC, MCI and semi-preparative HPLC were applied to isolate and purify- the compounds from Rh. devorum, and their chemical structures were elucidated based on their physicochemical properties and spectroscopic data. Results： Eight known compounds, including six diterpenoids, two nor-sesquiterpenoids were isolated from 95% EtOH extracts of Rh. decorum, and identified as grayanotoxin I（ 1 ）, grayanotoxin X（2）, grayanotoxin VIII（ 3 ）, rhodo- decorumin VII（4 ） leucotbol A （ 5 ）, grayanotoxin XXI （ 6 ）, （ ＋ ） -Dehydrovomifoliol （ 7 ）, 5 α, 6α-Epoxy-3β-hydroxy- megastigm-7-en-9-one（8）. Conclusion： Except for compound 4, all of the compounds were isolated from this genius for the first time.

关 键 词：大白杜鹃 二萜 降倍半萜 

分 类 号：R284.1[医药卫生—中药学]