疾病的发生发展与骨化三醇体内水平间的相互影响及其相关机制  

Correlation of endogenous calcitriol with the disease development

作　　者：律立红 徐智儒[1,2] LYU Li-hong;XU Zhi-ru(State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437;Shanghai Professional and Techniical Service Center for Biological Material Druggability Evaluation,Shanghai 200437,China)

机构地区：[1]中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200437 [2]上海市生物物质成药性评价专业技术服务中心,上海200437

出　　处：《世界临床药物》2018年第10期699-704,共6页World Clinical Drug

摘　　要：骨化三醇是维生素D_3的一种最重要的活性代谢物,是维生素D_3信号生物学功能的主要执行者,与人体内多种疾病相关,其在人体内的水平也受到多种疾病的影响。本文主要综述疾病的发生发展与骨化三醇体内水平间的相互影响及其相关机制。Calcitriol is one of the most important active metabolites of vitamin D3, which is responsible for the biological function of vitamin D3. Studies have shown that calcitriol is associated with many diseases, and its content in the human body is also affected by diseases. This review describes the function of endogenous calcitriol, and its interaction with the disease development.

关 键 词：维生素D3 1α 25-二羟基维生素D3[1α 25-(OH)2D3] 免疫性疾病 神经系统疾病 呼吸系统疾病 皮肤疾病 

分 类 号：R977.24[医药卫生—药品] R5[医药卫生—药学]