ICU超剂量谷红注射液成品输液的合理性考察  

Reasonablity study of overdosage Guhong injection in ICU

作　　者：陈娟[1] 周晔 陈伟华[3] 李宵[1] 佘晨欢 CHEN Juan;ZHOU Ye;CHEN Weihua(Hebei General Hospital,Hebei Province,Shijiazhnang 050051,China)

机构地区：[1]河北省人民医院药学部,石家庄市050051 [2]河北省直属机关第二门诊部功能科,石家庄市050051 [3]河北省人民医院检验科,石家庄市050051 [4]承德医学院临床学院,河北省承德市067000

出　　处：《临床合理用药杂志》2018年第31期12-15,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：2015年政府资助省级临床医学优秀人才项目

摘　　要：目的建立ICU超剂量谷红注射液与5%葡萄糖注射液、0. 9%氯化钠注射液配伍后的成品输液于室内(约25℃)光照下放置24 h,考察ICU超剂量用药的合理性。方法以谷红注射液成品输液中4种有效成分含量、外观、不溶性微粒、pH值变化情况为指标,对该成品输液的稳定性进行考察。结果各成品输液于24 h均为深红棕色澄清溶液,未见明显变化,未出现浑浊及沉淀;不溶性微粒超出药典规定范围;其4种有效成分含量均呈下降趋势。结论该超剂量谷红注射液成品输液于24 h稳定性明显欠佳,该用药不合理,故不建议ICU超剂量用谷红注射液。Objective To develop a method for determining reasonability of overdosage Guhong injection with 5% glucose injection and 0.9% NaC1 injection in indoor illumination within 24 h at room temperature （25 ℃） to examine the rationality of the overdosage drug in ICU. Methods The content of four active ingredients, appearance, insoluble particles and pH change in the finished product infusion of Guhong injection were used to indicate the stability of the finished product. Results All the finished products were dark reddish-brown elarifying solution in 24 h, no obvious change, no turbidity and precipitation. The insoluble particles exceeded the scope of the pharmacopoeia. The content of the four active components showed a decreasing trend. Conclusion It is not recommended to use overdosage Guhong injection in the ICU because of its unstability and unreseanability.

关 键 词：ICU 超剂量 谷红注射液 成品输液 合理性 

分 类 号：R472[医药卫生—护理学]