间充质干细胞来源胞外囊泡救治辐射损伤的研究进展  

Role of mesenchymal stem cell derived extracellular vesicles in radiation injuries

作　　者：王利[1,2] 马得勋[3] 许长春 高蕊 高春记 刘书锋[3] WANG Li;MA Dexun;XU Changchun;GAO Rui;GAO Chunji;LIU Shufeng(Department of Hematology and Oncology,Laoshan Branch of No.401 Hospital of Chinese PLA,Qingdao 266101 China;Department of Hematology,Chinese PZA General Hospital;Department of radiation protection,Laoshan Branch of No.401 Hospital of Chinese PLA)

机构地区：[1]解放军第401医院崂山分院血液肿瘤科,山东青岛266101 [2]解放军总医院血液科 [3]解放军第401医院崂山分院核防护科

出　　处：《中国辐射卫生》2018年第4期369-371,共3页Chinese Journal of Radiological Health

基　　金：国家自然科学基金(81270642;81070451);北京市自然科学基金(7162175);海南省社会发展基金(SF201306);解放军总医院百项优势项目(YS201451);军队后勤计划项目(cjn15j001)

摘　　要：间充质干细胞来源胞外囊泡(MSC-EV)在保留间充质干细胞(MSC)生物学功能的同时,能够避免MSC内在缺陷; MSC-EV脂质双分子层结构能够避免其脂质、蛋白、DNA、RNA等内容物被酶类物质降解;此外,MSC-EV适合通过永生化MSC技术进行大规模制备。因此,与MSC相比,MSC-EV是一种新型高效、安全、便捷、可行的非细胞治疗方法,且在组织修复及免疫调节方面呈现出同等功效。本文仅就MSC-EV在辐射损伤救治方面的研究进展作一综述。Mesenchymal stem cell derived extracellular vesicles（ MSC-EVs） conserve MSC＇ bioactivity,while overcome certain safety concerns related to MSC. The phospholipid bilayer of MSC-EVs may protect their contents,such as lipid,protein,DNA,RNA,from degradation by circulatory enzymes. Moreover,large scale MSC-EVs could be obtained through immortalized MSC technique. Thus,MSC-EVs based therapy is a more efficient,convenient,feasible,safer cell free therapy strategy compared with MSC. So far,MSC-EVs present similar function to MSC in the field of regenerative medicine and immunomodulation. Herein,the recent research progress about the role and the involved mechanisms of MSC-EVs in radiation injuries are systematically reviewed.

关 键 词：间充质干细胞 胞外囊泡 辐射损伤 

分 类 号：R818[医药卫生—放射医学]