放射治疗对NSCLC患者外周血Treg细胞水平的影响  

Effect of radiation therapy on Treg cells in peripheral blood of NSCLC patients

作　　者：陈英[1] 张芬[1] 孙义玲[1] 时勇[1] 张敏[1] 王洪建 CHEN Ying;ZHANG Fen;SUN Yiling;SHI Yong;ZHANG Min;WANG Hongjian(Tengzhou Central People＇s Hospital,Tengzhou 277599 China)

机构地区：[1]滕州市中心人民医院,山东滕州277599

出　　处：《中国辐射卫生》2018年第4期421-424,共4页Chinese Journal of Radiological Health

摘　　要：目的研究放射治疗对NSCLC患者外周血Treg细胞水平的影响。方法分析50例NSCLC患者放射治疗前后外周血CD4^+CD25^+Foxp3^+Treg/CD4^+比值的变化,及其与临床特征的关系。结果 NSCLC患者放射治疗后CD4^+CD25^+Foxp3^+Treg细胞占CD4^+T细胞的比例显著降低,与肿瘤直径、肿瘤分期及分化程度有关。结论 CD4^+CD25^+Foxp3^+Treg细胞水平在NSCLC放射治疗过程中变化显著,可能成为NSCLC预后的重要预测指标。Objective To study the effect of radiation therapy on peripheral blood Treg cells in NSCLC patients.Methods To analyze the changes of CD4＋ CD25＋ Foxp3＋ Treg/CD4＋ cells ratio in peripheral blood of 50 NSCLC patients before and after radiation therapy,and their relationship with clinical characteristics.Results The proportion of CD4＋ CD25＋ Foxp3＋ Treg cells in CD4＋ T cells was significantly decreased after radiotherapy in NSCLC patients,which was related to tumor diameter,tumor stage and differentiation.Conclusion The level of CD4＋ CD25＋ Foxp3＋ Treg cells significantly changed during NSCLC radiation therapy,which may be an important prognostic indicator of NSCLC.

关 键 词：放射治疗 NSCLC CD4^+CD25^+Foxp3^+Treg细胞 

分 类 号：Q691[生物学—生物物理学]