针刺内麻点联合塞来昔布超前镇痛对全膝关节置换术后患者VAS疼痛评分及IL-6含量的影响  

Preemptive Analgesia Effect on the VAS Score and IL-6 Content of Acupuncture at Neimadian Combined with Celecoxib in Postoperation of Total Knee Arthroplasty

作　　者：朱锦忠 徐洲发 肖智青 王凤龙 王爱明 刘勇 张俭 ZHU Jin-zhong;XU Zhou-fa;XIAO Zhi-qing;WANG Feng-long;WANG Ai-ming;LIU Yong;ZHANG Jian(The Department of Orthopedics,the Heyuan Hospital of Traditional Chinese Medicine,Hcyuan,Guangdong 517000)

机构地区：[1]广东省河源市中医院骨二区,河源517000

出　　处：《实用中西医结合临床》2018年第8期10-12,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药管理局科研项目(编号:20161249)

摘　　要：目的:探讨针刺内麻点联合塞来昔布超前镇痛对全膝关节置换(TKA)术后患者疼痛及炎性因子的影响。方法:选取2016年1~11月我院收治的45例单侧膝关节置换患者,随机分成针刺内麻点联合塞来昔布组(A组)、针刺非内麻点联合塞来昔布组(B组)和空白对照组(C组),每组15例。A组在术前3 d开始针刺内麻点并联合塞来昔布口服,B组在术前3 d开始针刺非内麻点(无关穴位)并口服塞来昔布,C组术前不作任何特殊处理。比较三组术前24 h及术后6、12、24、48 h的VAS疼痛评分,三组术前24 h及术后24 h白细胞介素-6的含量。结果:A组与B组术后VAS疼痛评分、白细胞介素-6含量均低于C组(P<0.05),且A组显著低于B组(P<0.05)。结论:针刺内麻点联合塞来昔布超前镇痛应用于全膝关节置换术后镇痛效果显著,能降低术后患者外周血中炎性因子的水平,其作用优于单纯使用塞来昔布镇痛。Objective： To explore the preemptive analgesia effect on the VAS score and IL-6 content of acupuncture at Neimadian（Extra） combined with celecoxib in postoperation of total knee arthroplasty. Methods： 45 Patients of total knee arthroplasty in our hospital from January to November 2016 were randomly divided into 3 groups： acupuncture at Neimadian（Extra） combined with celecoxib group（group A）, acupuncture at non-Neimadian combined with celecoxib group（group B）, and blank group（group C）, 15 cases in each group.Group A acupunctured at Neimadian combined with celecoxib taken orally from preoperative three days, group B in the preoperative 3 days began to acupuncture at non-Neimadian combined with celecoxib taken orally, group C did not make any special treatment. The VAS scores were compared in the three groups at preoperative 24 h, postoperative 6 h, 12 h, 24 h and 48 h, the levels of IL-6 in the three groups at preoperative 24 h and postoperative 24 h. Results： The levels of VAS score and IL-6 in group A and group B were lower than those in group C（P〈0.05）, and group A were lower than group B（P〈0.05）. Conclusion： There is analgesic significantly effect on the VAS score and IL-6 content of acupuncture at Neimadian（Extra） combined with celecoxib in postoperation of total knee arthroplasty, can reduce postoperative inflammatory factor levels in peripheral blood, its effect is superior to the simple use of celecoxib.

关 键 词：全膝关节置换术后 内麻点 塞来昔布 超前镇痛 IL-6 

分 类 号：R687.4[医药卫生—骨科学]