小檗碱对代谢综合征肾损害患者肠道双歧杆菌和炎症因子的影响  

Effects of berberine on intestinal bifidobacterium and inflammatory factors in metabolic syndrome patients with renal damage

作　　者：王丽萍[1] 黄春来 陈小青[1] 张勇[1] 邱妙华 庄永泽[1] WANG Liping;HUANG Chunlai;CHEN Xiaoqing;ZHANG Yong;QIU Miaohua;ZHUANG Yongze(Department of Nephrology of Fuzhou General Hospital,Fuzhou 350025,China)

机构地区：[1]福州总医院肾内科福建医科大学福总临床医学院,福州350025

出　　处：《肾脏病与透析肾移植杂志》2018年第5期440-444,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然基金面上项目(81373837);福建省自然科学基金面上项目(2018J01184);福建省临床重点专科建设项目

摘　　要：目的:探讨小檗碱对代谢综合征肾损害患者肠道双歧杆菌和炎症因子的影响,为小檗碱治疗代谢综合征肾损害提供理论依据。方法:选取2016年1月至12月福州总医院肾内科临床诊断符合代谢综合征肾损害的患者20例,随机分为基础治疗组(对照组)和小檗碱组(治疗组),每组各10例。对照组予基础治疗,治疗组在基础治疗的同时加用小檗碱,8周为一个疗程。同时选取在性别、年龄相匹配的健康体检者10例为正常组。结果:治疗8周后,治疗组患者体质量指数(BMI)、收缩压、舒张压、空腹血糖(FBG)、餐后2h血糖(2hPBG)、空腹胰岛素(FINS)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、尿微量白蛋白/肌酐比值(U-mAlb/Ucr)均明显下降(P<0. 05),对照组患者收缩压、舒张压、U-mALb/Ucr也明显下降(P<0. 05),两组患者BMI、FBG、2hPBG、FINS、TG、LDL-C变化具有统计学差异(P<0. 05)。用药8周后,治疗组血、尿白细胞介素6(IL-6)明显下降,而对照组未见明显变化(P<0. 05)。用药8周后,治疗组肠道双歧杆菌数量明显升高,而对照组未见明显升高(P<0. 05)。Spearman相关分析提示肠道双歧杆菌与血、尿IL-6均呈负相关。结论:小檗碱可增加代谢综合征肾损害患者肠道双歧杆菌的数量,降低血清及尿液炎症因子水平,并在一定程度上改善糖脂代谢紊乱,降低空腹胰岛素水平、减轻体重。Objective：To investigate the influence of berberine on intestinal bifidobacterinm and inflammatory factors in metabolic syndrome patients with renal damage. Methodology： Twenty metabolic syndrome patients with renal damage were randomly divided into basic treatment group （control group, n = 10） and berberine group （treatment group, n= 10） .Berberine was describe with basic treatment for 8 weeks.At the same time, 10 healthy persons who matched sex and age were selected as normal group. Results ： After 8 weeks of treatment, BMI, SBP, DBP, FBG, 2hPBG, FINS, TG, LDL-C and U-mALb/Ucr was decreased significantly in the treatment group （P〈0.05） ;SBP, DBP and U-mALb/Ucr in control group was also significantly decreased （P〈0. 05 ）.There were statistically significance.in BMI, FBG, 2hPBG, FINS, TG and LDL-C （P〈0. 05） between two groups.After 8 weeks of treatment, blood and urine IL-6 in change treatment group was decreased significantly, while that of control group did not change significantly （P〈0. 05）.After 8 weeks of treatment, the number of intestinal bifidobacteria in treatment group was increased significantly ,while that of control group did not significantly （P〈 0.05） .Spearman correlation analysis showed that the intestinal bifidobacteria were negatively correlated with blood and urine IL-6. Conclusion：Berberine can increase the number of intestinal bifidobacterium, and reduce of serum and urine IL-6 levels in patients with metabolic syndrome conbined with renal damage, improve metabolic disorder of glucose and lipid, reducing fasting insulin and body weight.

关 键 词：代谢综合征 肠道双歧杆菌 肾损害 小檗碱 

分 类 号：R589[医药卫生—内分泌] R692[医药卫生—内科学]