胰石蛋白在小儿脓毒症中的水平及意义  

Level of PSP/reg protein in children with sepsis and its significance

作　　者：孟宪梅 郭茹 杨湘峰[1] 张静[1] 熊岚[1] MENG Xian Mei;GUO Ru;YANG Xiang Feng;ZHANG Jing;XIONG Lan(Department of Pediatrics,Hunan Provincial Women and Children＇s Health Care Hospital,Changsha 410008,China)

机构地区：[1]湖南省妇幼保健院普儿科,长沙410008

出　　处：《中国妇幼卫生杂志》2018年第5期30-33,共4页Chinese Journal of Women and Children Health

摘　　要：目的探讨胰石蛋白(PSP/reg)在小儿脓毒症中的水平及意义。方法选取2016年2月-2017年12月在湖南省妇幼保健院PICU治疗的脓毒症患儿92例,其中严重脓毒症患儿38例(严重脓毒症组),脓毒症患儿54例(脓毒症组),同时选取非脓毒症患儿60例作为对照组,检测各组血浆PSP/reg水平。结果严重脓毒症组第1、3和7天血浆PSP/reg分别为87.05(63.23,118.50)ng/ml、89.01(57.10,120.43)ng/ml和52.18(32.10,94.52)ng/ml,明显高于对照组和脓毒症组,差异有统计学意义(P<0.05);死亡患儿第1、3和7天血浆PSP/reg分别为84.82(70.11,123.10)ng/ml、110.03(67.39,172.04)ng/ml和114.02(89.02,160.51)ng/ml,明显高于存活患儿,差异有统计学意义(P<0.05);器官衰竭数≥2个患儿第1、3和7天血浆PSP/reg分别为78.92(61.70,105.92)ng/ml、102.38(70.15,142.16)ng/ml和94.02(81.43,132.02)ng/ml,明显高于器官衰竭≤1个患儿,差异有统计学意义(P<0.05);第1天血浆PSP/reg判断脓毒症患儿预后的ROC曲线下面积为0.857,差异有统计学意义P<0.05,截断值60.80 ng/ml时,其判断患儿死亡的灵敏度和特异度分别为93.80%和68.42%。结论脓毒症患儿血浆PSP/reg水平明显升高,其与患儿病情严重程度和预后有一定关系,具有较高的临床应用价值。Objective To explore the level of pancreatic stone protein（ PSP/reg） in children with sepsis and its significance.Methods 92 cases of sepsis in PICU from February 2016 to December 2017 were selected,including 38 severe sepsis children（ severe sepsis group）,54 sepsis children（ sepsis group）. 60 children without sepsis were selected as the control group. The level of plasma PSP/reg was detected in each group. Results In the severe sepsis group,the plasma PSP/reg on the first day,the third day and the seventh day was 87. 05（ 63. 23,118. 50） ng/ml,89. 01（ 57. 10,120. 43） ng/ml and 52. 18（ 32. 10,94. 52） ng/ml,respectively. They were significantly higher than those in control group and sepsis group（ P〈0. 05）. The plasma PSP/reg on the first day,the third day and the seventh day in the death group was84. 82（ 70. 11,123. 10） ng/ml,110. 03（ 67. 39,172. 04） ng/ml and114. 02（ 89. 02,160. 51） ng/ml,respectively. They were significantly higher than those in the surviving children（ P〈0. 05）. The plasma PSP/reg on the first day,the third day and the seventh day in children with more than 2 organs failure were 78. 92（ 61. 70,105. 92） ng/ml,102. 38（ 70. 15,142. 16） ng/ml and 94. 02 L（ 81. 43,132. 02） ng/ml,respectively. They were significantly higher than those of children with less than one organ failure（ P〈0. 05）. The area of the ROC curve for plasma PSP/reg judging the prognosis of children with sepsis was 0. 857（ P〈0. 05）. Cut-off value was 60. 80 ng/ml. The sensitivity and specificity of judging the death of the children were 93. 80% and 68. 42%,respectively. Conclusion The level of plasma PSP/reg in children with sepsis is significantly higher,which has a certain relationship with the severity and prognosis of the children. It has a high clinical value.

关 键 词：胰石蛋白 脓毒症 预后 

分 类 号：R720.597[医药卫生—急诊医学]