养生益肾汤联合厄贝沙坦治疗早期糖尿病肾病临床研究  

Clinical study of Yangsheng-Yishen decoction combined with irbesartan in the treatment of early diabetic nephropathy

作　　者：吕娟[1] 张蕊[3] 曹兰 秀白甫 Lyu Juan;Zhang Rui;Cao Lanxiu;Bai Fu(Chinese Medicine Teaching and Research Section,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学中药教研室,咸阳712046 [2]陕西中医药大学方剂教研室,咸阳712046 [3]陕西中医药大学第二附属医院糖尿病科,咸阳712000

出　　处：《国际中医中药杂志》2018年第11期1033-1036,共4页International Journal of Traditional Chinese Medicine

基　　金：陕西省自然科学基础研究计划项目（2017JM8021）

摘　　要：目的 探讨益气活血方联合运动康复疗法对脑梗死恢复期患者偏瘫肢体功能恢复及表面肌电图（surface electromyography, sEMG）的影响。方法 将符合入选标准的80例脑梗死恢复期患者采用随机数字表法分为2组，每组40例。康复治疗组在对症治疗基础上配合偏瘫运动康复治疗，联合治疗组在康复治疗组基础上加服益气活血方。2组均1个月为1个疗程，共治疗3个疗程。分别于治疗前及各疗程结束后进行患侧上肢Fugl-Meyer量表（Fugl-Meyer Assessment, FMA）评分，采用表面肌电图仪检测偏瘫侧肱二头肌表面肌电图（surface electromyography, sEMG）最大等长收缩肌电图波形的均方根值（root mean square, RMS）和中位频率值（median frequency, MDF）。结果 治疗后1、2、3个月，联合治疗组FMA评分均高于康复治疗组（t值分别为2.702、4.595、4.444，P值均＜0.01）。治疗后2、3个月，联合治疗组RMS值（t值分别为7.188、5.405，P值均＜0.01）与MDF值（t值分别为3.336、4.584，P值均＜0.01）均高于康复治疗组。结论 益气活血方联合运动康复疗法可改善脑梗死恢复期患者偏瘫侧上肢的运动功能，提高肌张力。Objective To explore effect of Yiqi-Huoxue decoction in combination with exercise rehabilitation therapy on functional recovery of hemiplegic limbs and surface electromyography （Surface electromyography, sEMG） during cerebral infarction convalescence. Methods According to random number table, 80 cerebral infarction patients in convalescence stage who met the inclusion criteria were divided into the combination therapy group and rehabilitation therapy group, 40 in each group. Rehabilitation therapy group received hemiplegia rehabilitation therapy; combination therapy group took Yiqi-Huoxue decoction on the basis of rehabilitation treatment. The 2 groups were treated for 3 months. In hemiplegic upper limb, Fugl-Meyer Assessment （FMA） was scored and Root Mean Square （RMS） and Median Frequency （MDF） of sEMG on biceps brachii were tested before and after each course of treatment respectively. Results After 1-, 2-, or 3-month treatment, FMA score of combination therapy group was significantly higher than that of rehabilitation therapy group （t=2.702, 4.595, 4.444, respectively; all P〈0.01）. At 2 or 3 months after treatment, the RMS of combination therapy group （t=7.188, 5.405, respectively; all P〈0.01） and the MDF （t=3.336, 4.584, respectively; all P〈0.01） were significantly higher than that of rehabilitation therapy group. Conclusions The Yiqi-Huoxue decoction in combination with exercise rehabilitation therapy can improve motor function and muscle tension of hemiplegic limbs during cerebral infarction convalescence.

关 键 词：糖尿病肾病 养生益 肾汤 厄贝沙坦 疗效比较研究 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]