补阳还五汤对舒张性心力衰竭模型大鼠心脏舒张功能的影响  

Effect of Buyang-Huanwu decoction on cardiac diastolic function in rats with diastolic heart failure

作　　者：董昕[1] 王臻[1] 李洁白 沈晓旭[1] Dong Xin;Wang Zhen;Li Jiebai;Shen Xiaoxu(Dongzhimen Hospital,Beijing 100007,China)

机构地区：[1]北京中医药大学东直门医院心血管内科,100007

出　　处：《国际中医中药杂志》2018年第11期1055-1058,共4页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金（81473517）

摘　　要：目的 观察补阳还五汤对舒张性心力衰竭模型大鼠心脏舒张功能的影响。方法 将30 只SD大鼠随机抽样分为正常组10只、中药组6只、西药组6只及模型组6只。除正常组外，其余各组大鼠采用狭窄腹主动脉法制备舒张性心力衰竭模型。中药组灌胃补阳还五汤12.72 g/（kg？d），西药组灌胃酒石酸美托洛尔0.004 5 g/（kg？d），正常组、模型组灌胃等体积去离子水。1次/d，干预8周。采用超声心动图测量舒张性心力衰竭模型大鼠射血分数、二尖瓣舒张早期血流峰值与舒张晚期血流峰值（E/A）比值及二尖瓣环舒张早期运动速度与舒张晚期运动速度（e/a）比值；利用Langendorff心脏灌注装置记录舒张性心力衰竭模型大鼠离体心脏心率、左心室舒张最低压、左室舒张末压、左室内压最大下降速率及心室肌张力。结果 与模型组比较，中药组e/a值[（1.11±0.28）比（0.67±0.20）]升高（P＜0.05），心室肌张力[（0.86±0.64）g比（1.01±0.33）g]降低（P＜0.05）。结论 补阳还五汤可改善舒张性心力衰竭大鼠心脏的舒张功能，其机制可能与降低心室肌张力、改善心肌弛缓功能有关。Objective To investigate the effect of Buyang-Huanwu decoction on left ventricular diastolic function in DHF rats. Methods Thirty male Sprague-Dawley rats were randomly divided into the normal group （n=10）, the Chinese medicine group （n=6）, the western medicine group （n=6） and the model group （n=6）. Except for the normal group, the other groups got abdominal aorta stenosis. After 12 weeks, The Chinese medicine group was given Buyang-Huanwu decoction 12.72 g/（kg？d）, and the western medicine group was given metoprolo l 0.004 5 g/（kg？d）, and the normal group and the model control group were given water. After once daily for 8 weeks, echocardiography was used to measure EF, E/A ratio and e/a ratio. The heart rate, left ventricular diastolic pressure, left ventricular end-diastolic pressure, tension and maximal change in pressure of left ventricular were measured by Langendorff. Results Compared with the model group, the e/a value （1.11 ± 0.28 vs. 0.67 ± 0.20） of the Chinese medicine group significantly increased （P〈0.05）, and the ventricular muscle tension （0.86 ± 0.64 g vs. 1.01 ± 0.33 g） significantly decreased （P〈0.05）. Conclusions Buyang-Huanwu decoction could improve cardiac relaxation by reducing ventricular muscle tension, thus improving diastolic function of diastolic heart failure rats.

关 键 词：补阳还五汤 心力衰竭 离体心脏制备 心室肌张力 大鼠 

分 类 号：R285.5[医药卫生—中药学] R-332[医药卫生—中医学]