瑞舒伐他汀联合稳心颗粒对老年慢性心力衰竭疗效及血清VEGF、MMP-9、MMP-2、TIMP-1水平的影响  

Effects of rosuvastatin combined with wenxin granule on the elderly patients with chronic heart failure and its effects on the levels of serum VEGF,MMP-9,MMP-2 and TIMP-1

作　　者：童琳[1] TONG Lin(Department of Cardiology,the Third People＇s Hospital of Chengdu,Chengdu 610041,Sichuan,China)

机构地区：[1]成都市第三人民医院心内科,四川成都610041

出　　处：《中国老年学杂志》2018年第22期5377-5380,共4页Chinese Journal of Gerontology

基　　金：国家自然科学基金项目(No.81300243)

摘　　要：目的探讨瑞舒伐他汀联合稳心颗粒对老年慢性心力衰竭疗效及血清血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)-9、MMP-2、组织金属蛋白酶抑制剂(TIMP)-1水平的影响。方法选取74例老年慢性心力衰竭患者,根据随机数字法分为观察组和对照组,每组37例。对照组使用瑞舒伐他汀,观察组在此基础上联合稳心颗粒。比较两组临床疗效,血清VEGF、MMP-9、MMP-2、TIMP-1水平,心功能指标,明尼苏达心力衰竭生活质量问卷(MLHFQ)评分和6 min步行距离(6MWT)。结果治疗后,观察组临床总有效率显著高于对照组,血清VEGF、MMP-9、MMP-2水平显著低于对照组,TIMP-1水平显著高于对照组(均P<0. 05)。观察组左室射血分数(LVEF)水平显著高于对照组,左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESDD)水平显著低于对照组(P<0. 05)。观察组MLHFQ积分显著低于对照组,6MWT显著多于对照组(均P<0. 05)。两组不良反应率差异无统计学意义(P>0. 05)。结论老年慢性心力衰竭患者经瑞舒伐他汀联合稳心颗粒治疗后,能有效降低患者血清VEGF、MMP-9、MMP-2水平,升高TIMP-1水平,改善患者临床症状,临床疗效良好,安全性高。Objective To study the effects of rosuvastatin combined with wenxin granule on the elderly patients with chronic heart failure（ CHF） and its effects on the levels of serum vascular endothelial growth factor（ VEGF）,matrix metalloproteinase（ MMP）-9,MMP-2,and tissue inhibitor of metalloproteinase（ TIMP）-1. Methods Seventy-four elderly patients with CHF were randomly divided into observation and control groups. The control group was treated with rosuvastatin,and the observation group was given wenxin granules on the basis of control group. The levels of serum VEGF,MMP-9,MMP-2,TIMP-1,cardiac function,Minnesota Heart Failure Quality of Life Questionnaire（ MLHFQ） score and 6 min walking distance were compared between the two groups. Results After treatment,the total effective rate of observation group was significantly higher than that of control group[89.19%（33/37） vs 64.86%（24/37）; P〈0.05]. The levels of serum VEGF,MMP-9 and MMP-2 in observation group were significantly lower than those in control group [（ 71. 53 ± 7. 83） ng/L,（151. 24±14. 32）μg/L,（187.43±14.21） μg/L vs（94.56±9.38）ng/L,（162.43±16.87） μg/L,（345.17±31.04） μg/L;P〈0.05]. The level of TIMP-1 was significantly higher than that of control group [（4.07 ± 0.48） μg/L vs（ 3.62 ± 0.37） μg/L; P〈0.05]. The level of LVEF in observation group was significantly higher than that in control group（ P〈0.05）. The levels of LVEDD and LVESDD were significantly lower than those in control group（ P〈0.05）. The MLHFFQ score of observation group was significantly lower than that of control group[（51.17 ± 3.15） points vs（62.33 ± 3.87） points;P〈0.05],6 min walking distance was significantly higher than that of control group[（494.38±46.81）m vs（441.54±42.15）m; P〈0.05]. There was no significant difference in the adverse reaction rate between the two groups（P〈0.05）. Conclusions Rosuvastatin combined with wenxin granules could effectively reduce the levels of serum V

关 键 词：瑞舒伐他汀 稳心颗粒 慢性心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]