针药并用治疗原发性干燥综合征临床观察  

Clinical Observations on Combined Use of Acupuncture and Medicine for Primary Sjogren Syndrome

作　　者：张金焕 张剑勇[2] 谢静静[2] ZHANG Jin-huan;ZHANG Jian-yong;XIE Jing-jing(Guangzhou University of Traditional Chinese Medicine Fourth School of Clinical Medicine,Shenzhen 518033,China;Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第四临床医学院,深圳518033 [2]深圳市中医院,深圳518033

出　　处：《上海针灸杂志》2018年第12期1399-1404,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：深圳市医疗卫生三名工程项目(SZSM201612080)

摘　　要：目的观察针药并用治疗原发性干燥综合征患者的临床疗效。方法将100例原发性干燥综合征患者随机分为4组,每组25例,针灸组予以针刺治疗,中药组予以深圳市中医院院内制剂祛斑养阴颗粒治疗,针药组予以针刺和中药并用治疗,西药组予以常规西医治疗。4周为1个疗程,治疗3个疗程后判定总体临床疗效。观察中医证候临床疗效、干燥综合征患者报告指数(ESSPRI)、干燥综合征疾病活动指数(ESSDAI)评分、唾液流率、Schirmer试验、血清免疫球蛋白(Ig G)、血沉(ESR)、C反应蛋白(CRP)。结果针药组总有效率为92.0%,中药组总有效率为76.0%,针灸组总有效率为68.0%,西药组总有效率56.0%,针药组优于针灸组、中药组、西药组(P<0.05)。针药组在ESSPRI评分、中医证候积分、唾液流率、IgG、ESR、CRP改善方面明显优于其他组,差异有统计学意义(P<0.05)。结论针刺和中药并用可以有效改善患者临床疗效及相关指标,提高患者生活质量,是原发性干燥综合征患者安全有效的治疗方法。Objective To investigate the clinical efficacy of combined acupuncture and medicine in treating primary Sjogren syndrome. Method One hundred patients with primary Sjogren syndrome were randomized to 4 groups, 25 cases each. The acupuncture group was treated with acupuncture; the Chinese herbal medicine group, with freckle-removing and yin-nourishing granules prepared by Shenzhen hospital of traditional Chinese medicin; the acupuncture and medicine group, with combined acupuncture and medicine; the Western medication group with conventional Western drugs. One course of treatment consisted of four weeks. The overall clinical effectswere evaluate after three courses of treatment. The clinical therapeutic effects on TCM syndrome were observed. The EULAR Sj？gren’s Syndrome Patient Reported Index （ESSPRI） score and the EULAR Sj？gren’s Syndrome Disease Activity Index （ESSDAI） score were recorded. Schirmer＇s test was carried out. The salivary flow rate, serum immunoglobulin （IgG）, erythrocyte sedimentation rate （ESR） and C-reactive protein （CRP） were measured. Result The total efficacy rate was 92.0% in the acupuncture and medicine group, 76.0% in the Chinese herbal medicine group, 68.0% in the acupuncture group and 56.0% in the Western medication group. The therapeutic effect was better in the acupuncture and medicine group than in the acupuncture, Chinese herbal medicine and Western medication groups （P〈0.05）. TheESSPRI score, the TCM syndrome score, the salivary flow rate, IgG, ESR and CRP improved more in the acupuncture and medicine group compared with the acupuncture, Chinese herbal medicine and Western medication groups. The differences had statistical significance （P〈0.05）. Conclusion Combined use of acupuncture and medicine can effectively improve the clinical therapeutic effect, related indicators and quality of life in the patients. It is an effective and safe way to treat primary Sjogren syndrome.

关 键 词：针灸疗法 针药并用 干燥综合征 中医证候积分 干燥综合征患者报告指数 干燥综合征疾病活动指数 唾液流率 SCHIRMER试验 血清免疫球蛋白 血沉 C-反应蛋白 

分 类 号：R246.1[医药卫生—针灸推拿学]