补肾益智方对阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用  

Protective Effect of Bushen Yizhi Decoction on Brain Cholinergic System in Rat Model with Alzheimer's Disease

作　　者：胡镜清[1] 赖世隆[1] 王奇[1] 梁伟雄[1] 谢红[1] 

机构地区：[1]广州中医药大学DME中心,广州510405

出　　处：《广州中医药大学学报》1999年第3期201-204,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家"九五"重点攻关课题 !编号 96- 90 6- 0 9- 0 2

摘　　要：为探讨自制方补肾益智方 (由蛇床子、枸杞子、女贞子、人参、制首乌等组成 )治疗阿尔茨海默病(Alzheimerdisease ,AD)的可能神经生物学机制 ,应用乙酰胆碱酯酶组织化学染色方法 ,研究了该方对D -半乳糖合并鹅膏蕈氨酸损毁大脑Meynert基底核的实验性阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用 ,结果显示 :补肾益智方灌胃组大鼠脑内广泛区域的乙酰胆碱酯酶阳性神经纤维密度较模型对照组增加 (P <0 .0 5或P <0 .0 1) ,提示该方对AD模型脑内胆碱能神经元具有一定的保护作用。The protective effect of Bushen Yizhi Decoction(BYD)on brain cholinergic system in rat model with Alzheimer's disease(AD)was studied with histochemical technique to visualize acetylcholinesterase.AD rat model was established by intraperitoneral injection of D-galactose and ibotenic acid injection into bilateral Meynert nucles.The results showed that the density of acetylcholinesterase_containing fibers in extensive region of model rat brain treated with gastric perfusion of BYD was higher than that in model rat brain.This indicates BYD exerts a certain protective effect on brain cholinergic neuron in rat model with AD.

关 键 词：阿尔茨海默病 补肾药 补肾益智方 乙酰胆碱酯酶 

分 类 号：R277.791.6[医药卫生—中医学]