健脾祛浊解毒法对溃疡性结肠炎患者Fas/FasL表达的影响  

Effect of Invigorating Spleen and Removing Turbid and Detoxifying Method on Fas/Fasl Expression in Patients with Ulcerative Colitis

作　　者：朱叶珊 费亚军 费璇 郑皓 刘润华 崔小霞 安丽娜 吉梅 ZHU Yeshan;FEI Yajun;FEI Xuan;ZHENG Hao;LIU Runhua;CUI Xiaoxia;AN Lina;JI Mei(Digestive Department,Tangshan Hospital of Traditional Chinese Medicine,Hebei Province,Tangshan 063000,China;Department of Internal Medicine,Laoting Hospital of Traditional Chinese Medicine,Hebei Province,Laoting 063600,China;Department of Internal Medicine,Qianxi Hospital of Traditional Chinese Medicine,Hebei Province,Qianxi 064301,China;Department of Traditional Chinese Medicine,Hebei North University,Hebei Province,Zhangjiakou 075000,China)

机构地区：[1]唐山市中医医院脾胃科,河北唐山063000 [2]河北省乐亭县中医医院内科,河北乐亭063600 [3]河北省迁西县中医院内科,河北迁西064301 [4]河北北方学院中医系,河北张家口075000

出　　处：《中国中医药现代远程教育》2018年第23期94-95,共2页Chinese Medicine Modern Distance Education of China

基　　金：河北省科技计划项目【No.152777142】;河北省中医药管理局【No.2017126】

摘　　要：目的观察中药运用健脾祛浊解毒法治疗湿热内蕴型溃疡性结肠炎的临床疗效,并对其进行可能机制探讨。方法将60例湿热内蕴型溃疡性结肠炎患者随机分为治疗组30例和对照组30例。治疗组给予美沙拉嗪肠溶片口服联合健脾祛浊解毒法中药汤剂口服治疗,对照组给予美沙拉嗪肠溶片口服治疗,2组均以8周为1个疗程。观察2组的临床疗效、磁共振结果和Fas/Fas L表达。结果 2组患者的Fas及Fas L表达均显著降低,且治疗组低于对照组,差异具有统计学意义(P<0.05);治疗过程中,2组患者均未出现严重不良反应。结论中药运用健脾祛浊解毒法治疗湿热内蕴型溃疡性结肠炎的效果显著,值得临床推广使用,有进行下一步深入研究的价值。Objective To observe the clinical effect of invigorating spleen and removing turbid and detoxifying method on ulcerative colitis of damp-heat type and explore its possible mechanism. Methods 60 cases of ulcerative colitis with damp heat accumulation were followed. The machine was divided into 30 cases in the treatment group and 30 in the control group. The treatment group was given oral treatment of Mesalazin Enteric-coated Tablets oral combined with invigorating spleen and removing turbid and detoxifying method, and the control group was given oral administration of Mesalazin Enteric-coated Tablets orally. The 2 groups were treated with 8W as 1 course. The clinical symptoms, MRI findings and Fas / FasL expression of the 2 groups were observed. Results The expression of Fas and FasL in the two groups were significantly decreased, and the treatment group was lower than the control group. The difference was statistically significant （P 〈 0.05）. In the course of treatment, no serious adverse reactions were found in the 2 groups. Conclusion The effect of invigorating spleen and removing turbid and detoxifying method is significant in the treatment of hot and damp ulcerative colitis, and it is worth popularizing in clinical practice. It is meaningful to carry out further study in the next step.

关 键 词：湿热内蕴型 溃疡性结肠炎 磁共振结肠成像 FAS/FASL表达 泄泻 

分 类 号：R259[医药卫生—中西医结合]