血液学指标变化与重度子痫前期的关系  

Blood Test Changes in Women with Preeclampsia and Its Influence on Mother and Child

作　　者：姚长芳[1] 叶文凤[1] 汤艳红[1] 孙彩凤 YAO Chang-fang;YE Wen-feng;SUN Cai-feng(Department of Gynecology,The Third Affliated of Hospital of Soochow University,Changzhou 213000,Jiangsu Province,China)

机构地区：[1]苏州大学附属第三医院妇产科,江苏常州213000 [2]江苏省常州市妇幼保健医院,江苏常州213000

出　　处：《罕少疾病杂志》2018年第5期4-6,26,共4页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨血小板(PLT)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)检测的临床意义。方法选择2015年01月至2016年12月于常州市妇幼保健院产科分娩的80例重度子痫前期的孕妇作为研究对象,孕周小于34周为早发型重度子痫前期(EP)38例,孕周大于等于34周为晚发型重度子痫前期(LP)42例,随机抽取血压正常,无产科合并症的健康孕妇110例作为对照组。回顾性分析孕末期血液学指标的变化,对母儿并发症的影响。结果 (1)三组孕妇血检指标在孕末期比较,差异有统计学意义(P<0.05),早发组与晚发组子痫前期尿酸比较差异有统计学意义(P<0.05);(2)子痫前期组间并发症比较,高血压心脏病,子痫发生率差异有统计学意义(P<0.05)。胎盘早剥,HELLP综合征发生率无统计学意义(P>0.05)。(3)子痫前期组围产儿结局比较,低出生体重儿,胎儿窘迫,新生儿窒息发生率差异有统计学意义(P<0.05);围产儿死亡发生率差异无统计学意义(P>0.05)。结论重度子痫前期孕妇常伴血液学指改变,提示有必要对重度子痫前期孕妇行血液学指标检查(PLT, PT, APTT, ALT, AST, BUN, Cr, UA),其中尿酸是较好的预测子痫前期的重要指标,早期治疗有效防止母儿并发症。Objective To study PLT, PT, APTT, ALT, AST, BUN, Cr, UA changes in women with preeclampsia patients and its relationship with preeclampsia. Methods From January 2015 to December 2015 80 patients with preeclampsia who delivered in Chang Zhou Maternal and Child Health group, among which 38 cases were defined as early onset preeclampsia（EP）group and 42 cases were defined as late onset preeclampsia（LP） group. And 110 healthy women with same age and same stage of pregnancy were selected as the control group. Their blood pressure were normal and they had no obstetrical complications.Blood test and the major maternal-fetal complications were analyzed retrospectively. Results（1）There was significant difference on the the blood test of three groups of pregnancy women. There was significant difference on the UA test between LP and EP（P〈0.05）.（2）There was significant difference on the maternalfetal complications between LP and EP, which including hypertensive Heart Disease and eclampsia. Placental abruption and HELLP syndrome have no significant difference（P〈0.05）.（3） There was significant difference on the fetal complications between LP and EP, which including low birth weight infant, fetal distress and neonatal asphyxia. The rate of infant death have no significant difference between the two groups（P〈0.05）. Conclusion It is common that preeclampsia is complicated with blood test. Thus it is necessary to test PLT, PT, APTT, ALT, AST, BUN, Cr, UA in women with preeclampsia,UA is of the great significant importance. Early treatment can prevent maternal-fetal complications effectively.

关 键 词：子痫前期 血小板 凝血酶原时间 尿酸 

分 类 号：R714.245[医药卫生—妇产科学]