低共熔溶剂中3,4-二氢嘧啶-2(1H)-酮衍生物的绿色合成  

Green Synthesis of 3,4-Dihydropyrimidin-2(1H)-ketone Derivatives in Deep Eutectic Solvents

作　　者：腾召一 吴小云 尹晓刚 Teng Zhaoyi;Wu Xiaoyun;Yin Xiaogang(College of Chemistry and Materials Science,Guizhou Normal Universit;Guizhou Key Laboratory of Functional Materials Chemistry,Guiyang 550001,China)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《山东化工》2018年第22期21-22,共2页Shandong Chemical Industry

基　　金：贵州省大学生创新创业训练计划,201710663065号;贵州省科技合作项目(黔科合LH字[2016]7218)

摘　　要：反应在低共熔溶剂(氯化胆碱/尿素)中,以芳香醛、乙酰乙酸乙酯和脲为原料,三组分反应合成了一系列3,4-二氢嘧啶-2(1H)-酮衍生物,考察催化剂、温度、反应时间及原料物质的量对产率的影响,在最优条件下产率为98. 3%。A series of 3,4-dihydropyrimidine-2-（1H）-ketone derivatives was synthesized by three-component reaction in a eutectic solvent （choline chloride/urea） using aromatic aldehyde,ethyl acetoacetate and urea as raw materials.The effects of catalyst,temperature,reaction time,and molarity of the raw materials on the yield were investigated.The yield was 98.3% under the optimal conditions.

关 键 词：低共熔溶剂 三组分反应 BIGINELLI反应 

分 类 号：O629.32[理学—有机化学]