12,12-二乙氧基十二基-1-炔的制备  

Process for the Preparation of 12,12-Diethoxy-1-dodecyne

作　　者：王小华 刘阳[2] 阮金兰[2] Wang Xiao-hua;Liu Yang;Ruan Jin-lan(Wuhan Institute of Technology,Wuhan 430205,China;Wuchang University of Technology,Wuhan 430223,China)

机构地区：[1]武汉工程大学,武汉430205 [2]武昌理工学院,武汉430223

出　　处：《现代农药》2018年第6期13-14,39,共3页MODERN AGROCHEMICALS

摘　　要：12,12-二乙氧基十二基-1-炔是制备脐橙螟性信息素的重要中间体。介绍了合成该中间体的有效方法,采用1,10-癸二醇为起始原料,经氯化、氧化、O-烷基化、炔基化4步反应制得,总收率达50%。该方法原料价廉易得,路线较短,收率较高。12,12-Diethoxy-1-dodecyne is an important intermediate of the insect sex pheromone of the navel orangeworm. The title intermediate was synthesized from 1,10-decanediol via chlorination, PCC oxidation, O-alkylation, alkynylation. The total yield of the four synthetic steps reached 50%. The method had such advantages as cheap and ready available raw materials, short route, and high yield.

关 键 词：昆虫性信息素 PCC氧化 O-烷基化 12 12-二乙氧基十二基-1-炔 制备 

分 类 号：TQ221.24[化学工程—有机化工]