氟尿嘧啶诱导黏膜损伤及腹泻的分子机制和药物防治研究  

Advances of the molecular mechanism and medication prevention and treatment of fluorouracil-induced mucositis and diarrhea

作　　者：吴毕力 袁响林 WU Bi-li;YUAN Xiang-lin(Cancer Centre,Tongji Hospital,Tongfi College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤中心,武汉430030

出　　处：《中国临床药理学杂志》2018年第22期2650-2653,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：氟尿嘧啶(5-FU)是一种临床常见的化学治疗药物,能对肠道细胞等增殖速度较快的机体细胞产生强大的抑制作用,因此肠道黏膜损伤和腹泻是其常见副作用。本文综述了近年来5-FU导致黏膜损伤及腹泻的分子机制及药物防治的研究,以期为该领域的基础和临床研究工作者提供参考。Fluorouracil （5 -FU）, a commonly used first -line chemo- therapeutic drug, has a strong inhibitory effect on the body cells such as intestinal cells with fast proliferation rate. Thus, intestinal mucositis and diarrhea are the most common side effects of 5 -FU. This article reviewed the recent studies on the underlying molecular mechanisms of 5 - FU - induced intestinal mucositis and diarrhea, as well as the studies on its prevention or treatment, with a view to provide reference for basic and clinical studies in this field.

关 键 词：氟尿嘧啶 腹泻 黏膜损伤 药物治疗 

分 类 号：R979.1[医药卫生—药品]