慢性盐负荷对血压正常个体体内炎症因子的影响  

Effects of Chronic Salt Loading on Plasma Inflammatory Factors in Normotensive Adults

作　　者：吴冠吉[1] 牟建军[2] 刘富强[2] 郑树慧[2] 蒋伟[2] 张敏[2] WU Guan-ji;MU Jian-jun;LIU Fu-qiang;ZHENG Shu-hui;JIANG Wei;Zhang Min(Department of Cardiology,Xi＇an Central Hospital,Xi＇an（710003）,Shaanxi,China)

机构地区：[1]西安市中心医院心内科,陕西省710003 [2]西安交通大学第一附属医院心内科

出　　处：《中国循环杂志》2018年第11期1085-1088,共4页Chinese Circulation Journal

基　　金：国家自然科学基金项目(81370357;81570381)

摘　　要：目的:通过对血压正常个体进行低盐和高盐饮食干预,探索盐负荷对血压正常个体体内炎症因子肿瘤坏死因子α(TNF-α)、高敏C反应蛋白(hs-CRP)和单核趋化蛋白-1(MCP-1)的影响。方法:选取30例年龄在18～60岁的血压正常者参与为期3周的慢性盐负荷试验,包括基线调查3天,低盐饮食、高盐饮食各7天。根据其平均动脉压(MAP)于高盐期较低盐期升高幅度≥10%为标准分为盐敏感者(10例)和盐不敏感者(20例),分别于基线及各期末抽取空腹静脉血标本。血浆TNF-α和MCP-1用酶联免疫吸附(ELISA)法测定,血浆hs-CRP用免疫放射比浊法测定。结果:3O例受试者中盐敏感检出率占33%(10例)。盐敏感者和盐不敏感者干预各期血浆hs-CRP水平无明显变化;而TNF-α水平[盐敏感者:(168.4±67.8) pg/ml vs(42.1±26.7) pg/ml,P<0.01;盐不敏感者:(129.8±24.1) pg/ml vs(37.7±15.8) pg/ml,P<0.01)]和MCP-1水平[盐敏感者:(205.2±64.2 vs 166.3±48.5) pg/ml,P<0.01;盐不敏感者:(212.3±52.2 vs 143.6±55.9) pg/ml,P<0.01],两者均为高盐期较低盐期显著增高。盐敏感者和盐不敏感者间同期比较差异无统计学意义。结论:高盐饮食可诱发一种炎症状态,这种炎症状态可能独立于血压的盐敏感性之外。Objectives： To observe the effects of dietary sodium intake on plasma inflammatory factors including tumor necrosis factor alpha （TNF-α）, high-sensitivity C-reactive protein （CRP） and monocyte chemoattractant protein -1 （MCP-1） in normotensive adults. Methods： Thirty normotensive volunteers, aged 18 to 60 years old, were selected to undergo baseline survey, low- sodium diet （51.3 mmol per day） for 7 days, followed by high-sodium diet （307.8 mmol per day） for 7days. Subjects were classified as salt sensitive （SS, 10 subjects） or non-salt sensitive （NSS, 20 subjects） based on their mean arterial blood pressure （MAP） increase （SS： more than 10 percent increase at the end of the high-sodium phase compared with the end of low-sodium phase）. Fasting blood samples were taken on the first day of baseline and on the sixth day of the two intervention phases. Plasma TNF-α and MCP-1 concentration was measured using an enzyme-linked immunosorbent assay system, plasma hs- CRP concentration was measured by immune nephelometry. Results： The prevalence of SS is 33%. After salt loading, no significant change was found in the plasma hs-CRP concentrations; Whereas plasma TNF-α level increased significantly in both of the SS and NSS groups（pg/ml, [168.4＋67.8 vs 42.1±26.7], P〈0.01 and [129.8±24.1 vs 37.7±15.8], P〈0.01, respectively） ; Plasma MCP-1 was also significantly higher during the high-sodium than the low-sodium phase in both SS and NSS groups（pg/ml, [205.2±64.2 vs 166.3±48.5], P〈0.01and [212.3±52.2 vs 143.6±55.9], P〈0.01）. Conclusions： High-sodium diet can induce an inflammatory state independent of the salt sensitivity in normotensive subjects.

关 键 词：盐 炎症因子 盐敏感性 

分 类 号：R541.4[医药卫生—心血管疾病]